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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Effects of preceding stimulation on brain activation in response to colonic distention in humans
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Effects of preceding stimulation on brain activation in response to colonic distention in humans

机译：先前刺激对人结肠扩张反应中脑激活的影响

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OBJECTIVE: It has been suggested that the pattern of distension (moderate following mild and vice versa) might influence brain activation and the experience of hypersensitivity, offset analgesia, and anticipation. Nevertheless, how the pattern of stimulation affects sensitization and/or desensitization to visceral stimulation remains unknown. METHODS: In 45 nonclinical healthy participants (12 women, 33 men; 20-26 years old), brain processing of visceral sensation induced by colonic distension was examined using H2O positron emission tomography. Subjective feelings regarding the stimuli were also measured. The descending colon was stimulated using six patterns of three bag pressures (0, 20, and 40 mm Hg). To evaluate the neural sensitization to visceral stimulation arising from the precedence effect, the effects of a 20- or 40-mm Hg distention after a sham or 20- or 40-mm Hg distension were analyzed using statistical parametric mapping. The level of significance was set at a voxelwise level of p < .0001, with cluster extent sizes of k > 50. RESULTS: The midbrain, insula, and cerebellum, were more strongly activated by a 20-mm Hg distension with a preceding 40-mm Hg distention than by a 20-mm Hg distention without a preceding stimulation (p < .0001). Conversely, a sham stimulation after the experience of an intense stimulation activated the midcingulate cortex, compared with a sham stimulation without the experience of actual visceral stimulation (p < .0001). CONCLUSIONS: By directly comparing different patterns of visceral stimuli, preceding visceral stimuli may affect neural sensitization and/or desensitization in humans, including elevated midbrain, insula, and midcingulate cortex.
机译：目的：有人指出，扩张的方式（轻度后继为中等程度，反之亦然）可能会影响大脑的激活以及超敏反应，抵消性镇痛和预期的经历。然而，刺激的方式如何影响对内脏刺激的敏化和/或脱敏仍然未知。方法：在45名非临床健康参与者（12名女性，33名男性; 20-26岁）中，使用H2O正电子发射断层扫描检查了结肠扩张引起的内脏感觉的大脑处理。还测量了有关刺激的主观感受。使用三个袋压力（0、20和40 mm Hg）的六种模式刺激降结肠。为了评估由先验效应引起的对内脏刺激的神经敏感性，使用统计参数映射分析了假手术或20或40 mm Hg扩张后20或40 mm Hg扩张的影响。显着性水平设定为体素水平，p <.0001，簇范围大小为k>50。结果：20毫米汞柱充气会更强烈地激活中脑，岛状和小脑，前40个-mm Hg膨胀，而没有事先刺激的情况下20mm Hg膨胀（p <.0001）。相反，与没有实际内脏刺激的假刺激相比，经过强烈刺激后的假刺激激活了中扣带皮层（p <.0001）。结论：通过直接比较内脏刺激的不同模式，先前的内脏刺激可能会影响人类的神经敏化和/或脱敏，包括中脑，岛突和中扣带皮层升高。

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