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首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Ghrelin levels after a cold pressor stress test in obese women with binge eating disorder
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Ghrelin levels after a cold pressor stress test in obese women with binge eating disorder

机译：患有暴饮暴食症的肥胖女性进行冷压应激测试后的Ghrelin水平

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Objective: Ghrelin, a peptide hormone secreted mainly by the stomach, increases appetite and food intake. Surprisingly, ghrelin levels are lower in obese individuals with binge eating disorder (BED) than in obese non-BED individuals. Acute psychological stress has been shown to raise ghrelin levels in animals and humans. Our aim was to assess ghrelin levels after a cold pressor test (CPT) in women with BED. We also examined the relationship between the cortisol stress response and changes in ghrelin levels. Methods: Twenty-one obese (mean [standard deviation] body mass index = 34.9 [5.8] kg/m2) women (10 non-BED, 11 BED) underwent the CPT, hand submerged in ice water for 2 minutes. Blood samples were drawn for 70 minutes and assayed for ghrelin and cortisol. Results: There were no differences between the groups in ghrelin levels at baseline (-10 minutes). Ghrelin rose significantly after the CPT (F = 2.4, p =.024) peaking at 19 minutes before declining (F = 17.9, p .001), but there were no differences between the BED and non-BED groups. Area under the curve for ghrelin was not related to ratings of pain, stress, hunger, or desire to eat after CPT. In addition, there were no observed relationships between the area under the curves for ghrelin or cortisol after stress. Conclusions: Although there were no differences between BED groups, there was a significant rise in ghrelin in obese humans after a stressor, consistent with other recent reports suggesting a stress-related role for ghrelin.
机译：目的：Ghrelin是一种主要由胃分泌的肽激素，可增加食欲和食物摄入。出乎意料的是，患有暴饮暴食症（BED）的肥胖个体的生长素释放肽水平低于肥胖的非BED个体。急性心理压力已显示可增加动物和人类的生长素释放肽水平。我们的目的是在患有BED的女性中进行冷加压试验（CPT）后评估生长素释放肽的水平。我们还检查了皮质醇应激反应和生长素释放肽水平变化之间的关系。方法：二十一名肥胖（平均[标准偏差]体重指数= 34.9 [5.8] kg / m2）的妇女（10名非卧床，11名卧床）进行了CPT，将手浸入冰水中2分钟。抽取血样70分钟，并检测生长素释放肽和皮质醇。结果：基线（-10分钟）时，组间生长素释放肽水平无差异。在CPT（F = 2.4，p = .024）在下降之前的19分钟达到峰值（F = 17.9，p <.001）之后，Ghrelin显着上升，但BED组和非BED组之间没有差异。生长激素释放肽曲线下的面积与CPT后疼痛，压力，饥饿或进食欲望的等级无关。此外，应激后生长素释放肽或皮质醇的曲线下面积之间没有观察到的关系。结论：尽管BED组之间没有差异，但是在应激后肥胖的人中，ghrelin显着升高，这与最近的其他报道表明ghrelin的应激相关作用一致。

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