• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychosomatic Medicine: Journal of the American Psychosomatic Society >Does socioeconomic status relate to central serotonergic responsivity in healthy adults?
【24h】

Does socioeconomic status relate to central serotonergic responsivity in healthy adults?

机译：社会经济地位是否与健康成年人的中央血清素能反应有关？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: We tested whether low SES was associated with reduced central serotonergic responsivity in a community sample of adult men and women and the extent to which standardized measures of aggression and impulsivity mediate the association. METHODS: A total of 270 adults who were enrolled in a clinical trial on the neurobehavioral effects of lipid lowering were given a neuropharmacologic challenge (plasma prolactin response to orally administered fenfluramine) to measure serotonergic responsivity. Measures of family income and educational attainment were standardized and summed to derive an overall index of SES. Scores from the Brown-Goodwin Life History of Aggression interview, the Barratt Impulsiveness Scale, and the Angry Hostility subscale from the NEO Personality Inventory were also standardized and summed to form an aggression/impulsivity score. RESULTS: Low SES was correlated with low prolactin responses to the fenfluramine challenge in the full sample (r = .15) as well as in whites, men, and women evaluated separately. Although the standardized SES score was correlated inversely with aggression/impulsivity measure (r = -.19, p < .01), the association between SES and prolactin responses remained significant when statistical adjustments were made for age, gender, body mass index, and aggression/impulsivity scores. CONCLUSIONS: Blunted serotonergic responsivity is associated with low social class as measured by annual family income and educational attainment.
机译：目的：在成年男女社区样本中，我们测试了低SES是否与中枢血清血清素能反应性降低有关，以及攻击性和冲动性标准化措施在多大程度上介导了这种关联。方法：总共270名参加了关于降低脂类的神经行为影响的临床试验的成年人接受了神经药理学挑战（血浆对口服芬氟拉明的催乳激素反应），以测量血清素能反应性。对家庭收入和教育程度的衡量标准进行了标准化和汇总，以得出SES的总体指数。来自Brown-Goodwin的“侵略生活史”访谈的分数，Barratt冲动量表和NEO人格量表中的“愤怒敌意”子量表也被标准化并加起来形成攻击/冲动得分。结果：在全部样本（r = .15）以及白人，男性和女性分别评估的情况下，低SES与较低的催乳素对芬氟拉明激发的低反应性相关。尽管标准化的SES评分与攻击/冲动度量成反比关系（r = -.19，p <.01），但在对年龄，性别，体重指数和年龄进行统计学调整后，SES与催乳素反应之间的关联仍然很显着。攻击/冲动得分。结论：血清素能反应迟钝与低社会阶层有关，这是通过家庭年收入和受教育程度来衡量的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号