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Correlates of Perceived Health-Related Quality of Life in Post-treatment Lyme Encephalopathy

机译：莱姆脑病治疗后感知的健康相关生活质量的相关性

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Background: Marked functional impairment has been reported by patients with post-treatment Lyme disease syndrome (PTLDS). Objective: We sought to identify the clinical features that contribute most strongly to the impaired health status associated with PTLDS. Methods: Enrolled patients had a well-documented history of Lyme disease, prior treatment with at least 3 weeks with intravenous ceftriaxone, a positive IgG Western blot, and objective problems with memory. An index score to capture aggregate cognitive functioning, Short-Form 36 physical and mental component summary scores, and scores on other clinical and demographic measures were examined. Multiple linear regressions were performed to determine significant predictors of perceptions of impaired life functioning as delineated by the Short-Form 36. Results: Fatigue was the most important contributor to perceived impairments in overall physical functioning, and fatigue and depression significantly predicted perceived impairments in overall mental functioning. Conclusions: Because fatigue and depression contribute prominently to reports of impaired physical functioning and mental functioning among patients with PTLDS, clinicians should assess patients for these symptoms and consider targeting these symptoms in the selection of treatment interventions. Future controlled studies should examine the effectiveness of such agents for patients with PTLDS.
机译：背景：治疗后的莱姆病综合征（PTLDS）患者已经报告了明显的功能障碍。目的：我们寻求确定对与PTLDS相关的健康状况受损最重要的临床特征。方法：入选患者具有充分的莱姆病史，静脉注射头孢曲松治疗至少3周，IgG Western blot阳性和记忆力客观问题。检查了用于捕获总体认知功能的指数评分，简短的36个身体和精神成分摘要评分以及其他临床和人口统计学指标的评分。进行了多项线性回归，以确定简表36所描绘的对生活功能受损的感知的重要预测指标。结果：疲劳是导致整体身体机能受损的最重要因素，疲劳和抑郁显着预测了整体感知机能受损精神机能。结论：由于疲劳和抑郁是导致PTLDS患者身体功能和精神功能受损的重要原因，因此临床医生应评估患者的这些症状，并在选择治疗干预措施时考虑针对这些症状。未来的对照研究应检查此类药物对PTLDS患者的有效性。

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