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首页> 外文期刊>Psychosomatics >Thoughts of Death and Self-Harm in Patients With Epilepsy or Multiple Sclerosis in a Tertiary Care Center
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Thoughts of Death and Self-Harm in Patients With Epilepsy or Multiple Sclerosis in a Tertiary Care Center

机译：三级护理中心对癫痫或多发性硬化症患者的死亡和自我伤害的思考

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Background: Patients with epilepsy or multiple sclerosis (MS') have high risks of depression and increased risks of suicide, but little is known about their risks of suicidal ideation. Objective: We sought to (1) estimate the prevalence of thoughts of being better off dead or of self-harm among patients with epilepsy or MS, (2) identify risk factors for such thoughts, and (3) determine whether any risk factors interact with depression to predict such thoughts. Methods: A Cleveland Clinic database provided information on 20,734 visits of 6586 outpatients with epilepsy or MS Outcome measures were thoughts of death or self-harm (Patient Health Questionnaire [PHQ] item-9), and total score >= 10 for the 8 remaining PHQ items (probable major depression). Generalized estimating equations accounted for repeat visits in tests of associations of PHQ item-9 responses with depression age, sex, race, household income, disease severity, and quality of life. Results: Prevalence of thoughts of death or self-harm averaged 14.4% overall (epilepsy, 14.0% and MS, 14.7%). Factors associated with positive PHQ item-9 responses in epilepsy were depression and male sex, modified by poor quality of lye Factors associated with positive PHQ item-9 in MS were depression male sex, medical comorbidity, and poor quality of life; the effect of depression was worse with greater MS severity and being unmarried, Conclusions: Among patients with common neurologic disorders (epilepsy or MS), 14%-15% reported thoughts of death or self-harm associated with illness severity, depression, quality of life, male sex, and being unmarried. Such patients require further evaluation of clinical outcomes and effects of treatment.
机译：背景：患有癫痫或多发性硬化症（MS'）的患者有很高的抑郁风险和自杀风险，但对其自杀意念的风险知之甚少。目的：我们试图（1）估计癫痫或MS患者中死于病态或自我伤害的想法的普遍性;（2）识别出这种想法的危险因素;（3）确定是否有任何危险因素相互影响用抑郁来预测这样的想法。方法：克利夫兰诊所数据库提供了6586名癫痫或MS门诊患者的20734次就诊信息。结果是死因或自我伤害的想法（患者健康问卷[PHQ] item-9），并且剩余8分的总得分> = 10 PHQ项目（可能是严重抑郁症）。广义估计方程解释了PHQ第9项反应与抑郁年龄，性别，种族，家庭收入，疾病严重程度和生活质量之间的关联测试中的重复访问。结果：死亡或自残思想的总体患病率平均为14.4％（癫痫症为14.0％，MS为14.7％）。癫痫患者中PHQ item-9阳性反应的相关因素为抑郁和男性，而碱液质量较差。MS患者中PHQ item-9阳性相关的因素为抑郁男性，医疗合并症和生活质量较差。结论：在患有常见神经系统疾病（癫痫或MS）的患者中，有14％-15％的患者认为死亡或自残与疾病的严重程度，抑郁，精神病的质量有关，抑郁症的影响更严重，且未婚。生活，男性和未婚。这些患者需要进一步评估临床结果和治疗效果。

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