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Treating the physical symptoms of depression with second-generation antidepressants: a systematic review and metaanalysis.

机译：用第二代抗抑郁药治疗抑郁症的身体症状：系统评价和荟萃分析。

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BACKGROUND: Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes. OBJECTIVE: The authors reviewed the effect of newer antidepressants on pain in patients with depression. METHOD: The authors searched systematically for trials of second-generation antidepressants that enrolled depression patients and reported pain outcomes, pooling changes on the pain visual-analog scale (VAS), using random-effects models. RESULTS: Eight trials were eligible. Pooled analysis of head-to-head trials showed no difference in VAS between duloxetine and paroxetine. Both drugs were superior to placebo. CONCLUSION: The authors found insufficient evidence to support the choice of one second-generation antidepressant over another in patients with pain accompanying depression.
机译：背景：大约三分之二的抑郁症患者会经历身体疼痛症状。并存的疼痛使抑郁症的治疗复杂化，并伴有抑郁症的恶化。目的：作者综述了新型抗抑郁药对抑郁症患者疼痛的影响。方法：作者使用随机效应模型，系统地搜索了招募抑郁症患者并报告疼痛结果的第二代抗抑郁药的试验，并在疼痛视觉模拟量表（VAS）上汇总了变化。结果：八项试验符合条件。头对头试验的汇总分析显示，度洛西汀和帕罗西汀之间的VAS没有差异。两种药物均优于安慰剂。结论：作者发现在抑郁症伴有疼痛的患者中，没有足够的证据支持选择一种第二代抗抑郁药而不是另一种抗抑郁药。

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