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A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients.

机译：舍曲林预防中风患者抑郁症的双盲，安慰剂对照研究。

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The authors tested the effect of sertraline in the prevention of poststroke depression. After experiencing an acute ischemic stroke, nondepressed patients (N=137) were randomly assigned to 12 months of double-blind treatment with either sertraline (N=70) or placebo (N=67). Kaplan-Meier analysis showed sertraline to have significantly superior prophylactic efficacy compared with placebo. Two definitions of clinical depression were used: total score >18 on the HAM-D(17) and score >or=9 on the HAM-D(6). Approximately 10% of the sertraline-treated group developed depression according to either definition, whereas 30% developed depression in the placebo group. On the HAM-D(6) the superiority of sertraline to placebo was demonstrated already after 6 weeks of therapy. Treatment was well tolerated; patients treated with sertraline experienced significantly fewer adverse events.
机译：作者测试了舍曲林在预防中风后抑郁中的作用。经历急性缺血性中风后，将非抑郁症患者（N = 137）随机分配至12个月的舍曲林（N = 70）或安慰剂（N = 67）的双盲治疗。 Kaplan-Meier分析显示舍曲林与安慰剂相比具有明显优越的预防功效。使用了两种临床抑郁症的定义：HAM-D（17）的总得分> 18，HAM-D（6）的总得分≥9。根据任一定义，舍曲林治疗组约有10％患上抑郁症，而安慰剂组约30％患上抑郁症。在HAM-D（6）上，治疗6周后，舍曲林优于安慰剂。治疗耐受性良好;舍曲林治疗的患者发生的不良事件少得多。

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