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首页> 外文期刊>Psychosomatics >Plasma levels of citalopram in depressed patients with hepatitis C.
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Plasma levels of citalopram in depressed patients with hepatitis C.

机译：抑郁丙型肝炎患者西酞普兰的血浆水平

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Hepatitis C affects an estimated 4 million Americans and 100 million people worldwide. Rates of depression are higher than that seen in the general population. Antidepressant therapy is often initiated at lower doses in patients with liver disease because of concerns about impaired metabolism and clearance. This study assessed plasma levels of citalopram in 15 subjects with hepatitis C and major depression during an 8-week trial. The mean citalopram dose at study completion was 26.67 mg/day. Mean plasma levels of citalopram, compared with levels previously reported, were lower than expected (at 10 mg/day [N = 1]: 21 ng/ml [N = 1]; at 20 mg/day [N = 8]: mean = 42.25 ng/ml, SD = 18.38; at 30 mg/day [N = 1]: 54 ng/ml; at 40 mg/day [N = 5]: mean = 76.2 ng/ml, SD = 35.86). There was a tendency for lower plasma levels to be found in those subjects receiving interferon, although a statistically significant difference was not observed. Citalopram was well tolerated. The results of this study suggest that patients with major depression and hepatitis C, but without evidence of severe liver disease, may be able to tolerate usual recommended doses of citalopram, thus avoiding the potential for undertreatment of the depression.
机译：丙型肝炎影响着全球约400万美国人和1亿人。抑郁症的发生率高于普通人群。由于担心代谢和清除能力受损，肝病患者通常以较低剂量开始抗抑郁治疗。这项研究在为期8周的试验中评估了15名患有丙型肝炎和严重抑郁症的受试者的西酞普兰血浆水平。研究完成时西酞普兰的平均剂量为26.67 mg /天。与先前报道的水平相比，西酞普兰的平均血浆水平低于预期（10 mg /天[N = 1]：21 ng / ml [N = 1]; 20 mg /天[N = 8]：平均值＝ 42.25ng / ml，SD ＝ 18.38;在30mg /天[N ＝ 1]：54ng / ml;在40mg /天[N ＝ 5]：平均值＝ 76.2ng / ml，SD ＝ 35.86。尽管未观察到统计学上的显着差异，但在接受干扰素的受试者中有发现血浆水平降低的趋势。西酞普兰的耐受性良好。这项研究的结果表明，患有重度抑郁症和丙型肝炎但没有严重肝病迹象的患者可能能够耐受通常推荐的西酞普兰推荐剂量，从而避免了抑郁症治疗不足的可能性。

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