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Cognition Predicts Quality of Life Among Patients With End-Stage Liver Disease

机译：认知预测终末期肝病患者的生活质量

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Background: Impaired cognitive functioning and poor quality of life (QoL) are both common among patients with end-stage liver disease; however, it is unclear how these are related. Objective: This study examines how specific cognitive domains predict QoL among liver transplant candidates by replicating Stewart and colleagues' (2010) 3-factor model of cognitive functioning, and determining how variability in these cognitive domains predicts mental health and physical QoL. Methods: The sample included 246 patients with end stage liver disease who were candidates for liver transplant at a large, Midwestern health care center. Measures, including the Repeatable Battery for the Assessment of Neuropsychological Status, Trail Making Test, Shipley Institute of Living Scale, Short-Form Health Survey-36 Version 2, and Hospital Anxiety and Depression Scale, comprised latent variables representing global intellectual functioning, psychomotor speed, and learning and memory functioning. Results: Confirmatory factor analysis results indicate that the 3-factor solution model comprised of global intellectual functioning, psychomotor speed, and learning and memory functioning fit the data well. Addition of physical and mental health QoL latent factors resulted in a structural model also with good fit. Results related physical QoL to global intellectual functioning, and mental health QoL to global intellectual functioning and psychomotor functioning. Conclusions: Findings elucidate a relationship between cognition and QoL and support the use of routine neuropsychological screening with end-stage liver disease patients, specifically examining the cognitive domains of global intellectual, psychomotor, and learning and memory functioning. Subsequently, screening results may inform implementation of targeted interventions to improve QoL.
机译：背景：终末期肝病患者常见认知功能障碍和生活质量（QoL）差。但是，目前尚不清楚它们之间的关系。目的：本研究通过复制Stewart及其同事（2010年）的认知功能三因素模型，并确定这些认知域中的变异性如何预测心理健康和身体QoL，来研究特定认知域如何预测肝移植候选者的QoL。方法：该样本包括246名患有晚期肝病的患者，这些患者在中西部大型医疗保健中心接受肝移植。包括可重复使用的神经心理状态评估电池组，追踪测试，Shipley生活研究所量表，短期健康调查-第3版第2版以及医院焦虑和抑郁量表在内的措施包括代表全球智力运行，心理运动速度的潜在变量。以及学习和记忆功能。结果：验证性因素分析结果表明，由全局智力功能，心理运动速度以及学习和记忆功能组成的三因素解决方案模型非常适合数据。身体和精神健康QoL潜在因素的增加也导致结构模型也具有良好的拟合度。结果将身体QoL与全球智力功能相关，并将心理健康QoL与全球智力功能和心理运动功能相关。结论：研究结果阐明了认知与生活质量之间的关系，并支持对末期肝病患者进行常规神经心理学筛查，特别是检查整体智力，心理运动以及学习和记忆功能的认知范围。随后，筛查结果可能有助于实施有针对性的干预措施以改善生活质量。

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