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Psychiatric Disorders and Health-Related Quality of Life in Children With Type 1 Diabetes Mellitus

机译：1型糖尿病儿童的精神疾病和与健康有关的生活质量

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Background: Type 1 diabetes mellitus (T1DM) is a chronic condition with major effect on health-related quality of life (HRQoL) and mental health. In 1990s, high rates of psychiatric disorders were reported among children with T1DM. Little is known, however, about current prevalence of psychiatric disorders in children with T1DM and the relation between psychiatric diagnosis and HRQoL. Objective: The aim of the study was to determine the prevalence of Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) psychiatric disorders and the association between psychiatric comorbidity and HRQoL in the pediatric population with T1DM. Methods: We conducted a cross-sectional study of 207 children, aged 8-18 years, diagnosed with T1DM. The presence of psychiatric disorders has been assessed by the standard diagnostic interview according to Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) criteria. HRQoL was measured by the general and diabetes mellitus-Tspecific modules of the Paediatric Quality of Life Inventory. Results: Of the evaluatedpatients, 26.6% (N= 55) met the criteria for psychiatric disorders at the time of evaluation. The most common diagnoses were anxiety (N = 32; 15.5%) and mood disorders (N = 8; 3.9%). One-third of the patients (N = 66, 31.9%) met the criteria for at least 1 psychiatric diagnosis in their lifetime. The presence of psychiatric disorders was related to an elevated hemoglobin A1c level (8.6% vs 7.6%) and a lowered HRQoL level in the general pediatric quality of life inventory. In the diabetes mellitus-speqfic pediatric quality of life inventory, children with psychiatric disorders revealed more symptoms of diabetes mellitus, treatment barriers, and lower adherence than children without psychiatric disorders. Conclusions: T1DM in children is associated with a very high prevalence of psychiatric comorbidity, which is related to elevated hemoglobin A1c and lower HRQoL levels.
机译：背景：1型糖尿病（T1DM）是一种慢性病，对健康相关的生活质量（HRQoL）和心理健康产生重大影响。在1990年代，据报告患有T1DM的儿童中精神疾病的发生率很高。然而，对于目前患有T1DM的儿童中精神疾病的患病率以及精神病诊断与HRQoL之间的关系知之甚少。目的：该研究的目的是确定精神疾病诊断和统计手册（第四版，文本修订）在精神疾病中的患病率以及儿童合并T1DM的精神疾病合并症与HRQoL之间的关系。方法：我们对207名年龄在8-18岁的被诊断患有T1DM的儿童进行了横断面研究。根据《精神障碍诊断和统计手册》（第四版，文本修订）标准，通过标准的诊断性访谈对精神障碍的存在进行了评估。 HRQoL是通过《儿童生活质量量表》的一般模块和糖尿病特定模块测量的。结果：在评估的患者中，有26.6％（N = 55）符合评估时精神疾病的标准。最常见的诊断是焦虑（N = 32; 15.5％）和情绪障碍（N = 8; 3.9％）。三分之一的患者（N = 66，31.9％）符合其一生中至少进行过1次精神病诊断的标准。精神疾病的存在与一般儿童生活质量清单中血红蛋白A1c水平升高（8.6％比7.6％）和HRQoL水平降低有关。在患有糖尿病的小儿生活质量调查中，患有精神疾病的儿童比没有精神疾病的儿童表现出更多的糖尿病症状，治疗障碍和依从性降低。结论：儿童T1DM与精神病合并症的患病率很高有关，这与血红蛋白A1c升高和HRQoL水平降低有关。

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