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首页> 外文期刊>Psychosomatics >Olanzapine for the treatment of psychosis in patients with Parkinson's disease and dementia.
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Olanzapine for the treatment of psychosis in patients with Parkinson's disease and dementia.

机译：奥氮平用于治疗帕金森氏病和痴呆症患者的精神病。

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摘要

Psychotic symptoms are a common complication in Parkinson's disease with dementia. The authors conducted an open-label 6-week trial of olanzapine preceded by a placebo lead-in in five subjects with Parkinson's disease, mild to moderately severe dementia, and psychosis. Four of the subjects terminated the trial early because of worsening motor function, sedation, or paranoia. There was no improvement in psychotic symptoms, and functional abilities declined significantly. Olanzapine appears to be poorly tolerated in patients with Parkinson's disease, psychotic symptoms, and dementia.
机译：精神病性症状是帕金森氏痴呆症的常见并发症。作者对5名患有帕金森氏病，轻度至中度重度痴呆和精神病的受试者进行了奥氮平开放性标签为期6周的试验，然后进行了安慰剂导入。由于运动功能恶化，镇静或妄想症，其中四名受试者提前终止了试验。精神病症状无改善，功能能力明显下降。患有帕金森氏病，精神病性症状和痴呆症的患者对奥氮平的耐受性差。

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