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首页> 外文期刊>Ultrasound in Medicine and Biology >Erosion of artificial endothelia in vitro by pulsed ultrasound: acoustic pressure, frequency, membrane orientation and microbubble contrast agent dependence.
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Erosion of artificial endothelia in vitro by pulsed ultrasound: acoustic pressure, frequency, membrane orientation and microbubble contrast agent dependence.

机译：脉冲超声在体外对人造内皮的侵蚀：声压，频率，膜取向和微泡造影剂依赖性。

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摘要

The erosion of cells from fibroblast monolayers simulating the vascular endothelium by 20 micros pulses of ultrasound at 500 Hz PRF was studied in relation to the peak negative acoustic pressure (P-; 0.0-2.5 MPa), ultrasound (US) frequency (1.0, 2.1 or 3.5 MHz), orientation of the monolayer (i.e., simulating the sites of ultrasound entry/exit from a blood vessel) and the presence or absence of a microbubble contrast agent (3 Vol% Albunex). The a priori hypotheses were that erosion of the monolayers would: 1. arise due to insonation treatment, 2. arise as a consequence of cavitation activity and, thus, increase with increasing P- at constant frequency, and decrease with increasing frequency at constant P-, 3. be significantly increased by the presence of a microbubble contrast agent, and 4. have a weak dependence on monolayer orientation. The data support these hypotheses. Under the most severe exposure conditions used, most of the affected cells appeared to have been lysed; however, a substantial number of viable cells were dislodged from the monolayer surface.
机译：针对峰值负声压（P-; 0.0-2.5 MPa），超声（US）频率（1.0，2.1），研究了在500 Hz PRF下通过20微脉冲超声对成纤维细胞单层细胞模拟血管内皮的侵蚀或3.5 MHz），单层的方向（即模拟超声波从血管进入/离开的部位）以及是否存在微泡造影剂（3 Vol％Albunex）。先验假设是单层的腐蚀将：1.由于声波处理而产生; 2.由于空化作用而产生，因此，在恒定频率下随着P-的增加而增加，在恒定P下随着频率的增加而减少。 -，3。由于存在微泡造影剂而明显增加，并且4.对单层取向的依赖性较弱。数据支持这些假设。在最严酷的暴露条件下，大多数受影响的细胞似乎已经裂解。然而，大量的活细胞从单层表面移出。

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