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首页> 外文期刊>Ultrasound in Medicine and Biology >Contrast-enhanced ultrasound for guidance of local tumor ablation.
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Contrast-enhanced ultrasound for guidance of local tumor ablation.

机译：对比增强超声引导局部肿瘤消融。

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The objective was to assess the efficacy of sonography with and without contrast medium enhancement in guiding and monitoring percutaneous ethanol ablation of tumors in an animal model. VX-2 carcinoma was implanted into the thighs of New Zealand white rabbits and examined by grey-scale ultrasound, color, power, and pulse Doppler, before and after injection of 95% ethanol into the tumors. Injections of ethanol were guided by ultrasound to sites of tumor vascularity, until all tumor vascularity had been obliterated. Microbubble contrast medium or saline was injected i.v. prior to each of the ultrasonic interrogations. Arteriography was performed before and after ablation. Selected tumor samples were submitted for histologic examination. Contrast enhanced tumor vascularity over saline controls in all cases. In some, incompletely ablated foci of tumor could only be identified with contrast medium enhancement. Arteriography showed complete ablation of all but 1 tumor. We conclude that ultrasound enhanced by contrast better shows the presence or absence of tumor vascularity. Ultrasound enhanced by contrast might offer an accurate means of guiding and monitoring percutaneous ethanol injection for tumor ablation.
机译：目的是评估在有和没有造影剂增强的情况下超声检查在动物模型中引导和监测经皮乙醇消融的功效。将VX-2癌植入新西兰大白兔的大腿中，并在向肿瘤注射95％乙醇之前和之后通过灰度超声，彩色，能量和脉冲多普勒检查。超声引导乙醇注射到肿瘤血管位置，直到所有肿瘤血管被消除。静脉内注射微泡造影剂或盐水。在每次超声波询问之前。在消融之前和之后进行动脉造影。选择的肿瘤样品被提交进行组织学检查。在所有情况下，相比于生理盐水对照，增强的肿瘤血管形成。在某些不完全消融的肿瘤灶中，只能通过增强造影剂来确定。动脉造影显示除1个肿瘤外所有肿瘤均已完全消融。我们得出的结论是，对比增强超声能更好地显示肿瘤血管的存在或不存在。通过对比增强的超声可能会提供一种指导和监测经皮乙醇注射消融的准确方法。

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