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首页> 外文期刊>Ultrasound in Medicine and Biology >A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy.
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A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy.

机译：高强度聚焦超声联合放疗的临床前体内研究。

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摘要

This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region.
机译：这项研究旨在进行体内研究，以评估高强度聚焦超声（HIFU）与放射疗法（RT）结合对猪胰腺和邻近组织的损伤。该方案已获得北京大学第一医院动物伦理委员会的批准。将总共​​12只家猪分为四组：对照组，仅HIFU，仅RT和HIFU + RT。根据总体和组织学检查结果评估HIFU声波对胰腺，邻近组织和组织的损伤。对于胰腺的目标区域，联合组的得分高于HIFU组，并且有显着差异。对于声路组织，除了对照组和其他组之间没有显着差异。 HIFU联合RT可增加对目标胰腺的损伤，而不会增加对目标区域以外组织的损伤。

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