...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Ultrasound in Medicine and Biology >Liver contrast enhanced ultrasound perfusion imaging in the evaluation of chronic hepatitis C fibrosis: preliminary results.
【24h】

Liver contrast enhanced ultrasound perfusion imaging in the evaluation of chronic hepatitis C fibrosis: preliminary results.

机译：肝造影剂增强超声灌注成像在慢性丙型肝炎纤维化评估中的初步结果。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We wanted to determine whether liver contrast-enhanced ultrasound (CEUS)-derived peak signal intensity (PSI) and peak signal intensity/time (PIT) predict liver fibrosis in chronic hepatitis C (CHC). Forty-nine patients with CHC (METAVIR classification) and 10 control subjects were included in the study. After a bolus of 2.4 mL SonoVue (Bracco Imaging, Milan, Italy) solution was injected into a peripheral vein, the right lobe of the liver containing the right portal vein was scanned in a transverse section. Two-dimensional sonography was performed using the Philips iU22 ultrasound system (Philips Healthcare, Best, the Netherlands). A 1.0-5.0-MHz (C5-1) wideband convex transducer was used, applying the following settings in all cases. Regions of interest were manually drawn over the right liver lobe and over the portal vein (PV). Liver parenchyma PSI (LPpsi) and PIT (LPpit), portal vein PSI (PVpsi) and PIT (PVpit) were automatically calculated. deltaPSI was defined as the difference between PVpsi and LPpsi. A significant correlation was observed between PA(PSI) and fibrosis scores. When patients were stratified according to their LPpsi, a significant difference was achieved only between patients with fibrosis score 0-1 vs. 2-3 and 2 vs. 4. Statistically significant differences between all fibrosis scores, except 0 vs. 1 and 3 vs. 4 were observed when deltaPSI was used to stratify patients. Overall diagnostic accuracy of LPpsi and deltaPSI measurement for severe fibrosis by area under the receiving operator characteristic curve analysis was, respectively, 0.87 and 0.88. We suggest that liver CEUS perfusion could have the potential to be used as a complementary tool for the evaluation of liver fibrosis. However, further large-scale studies are required to accurately assess its accuracy in the evaluation of liver fibrosis.
机译：我们想要确定肝造影增强超声（CEUS）衍生的峰值信号强度（PSI）和峰值信号强度/时间（PIT）是否可预测慢性丙型肝炎（CHC）的肝纤维化。该研究包括49名CHC患者（METAVIR分类）和10名对照受试者。将2.4 mL大剂量SonoVue（Bracco Imaging，米兰，意大利）溶液注入周围静脉后，在横断面扫描包含右门静脉的肝脏右叶。使用Philips iU22超声系统（Philips Healthcare，Best，荷兰）进行二维超声检查。使用1.0-5.0-MHz（C5-1）宽带凸换能器，在所有情况下均应采用以下设置。在右肝叶和门静脉（PV）上手动绘制感兴趣区域。自动计算肝实质PSI（LPpsi）和PIT（LPpit），门静脉PSI（PVpsi）和PIT（PVpit）。 deltaPSI被定义为PVpsi和LPpsi之间的差异。 PA（PSI）与纤维化评分之间存在显着相关性。根据LPpsi对患者进行分层时，只有纤维化评分0-1与2-3、2与4之间的患者之间才有显着性差异。除0与1和3与3之间的差异外，所有纤维化评分之间在统计学上均具有显着性差异。当使用deltaPSI对患者进行分层时，观察到4。在接受操作者特征曲线分析下，按面积分的LPpsi和deltaPSI测量的总体诊断准确度分别为0.87和0.88。我们建议肝脏CEUS灌注可能有潜力用作评估肝纤维化的补充工具。但是，需要进一步的大规模研究来准确评估其在肝纤维化评估中的准确性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号