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首页> 外文期刊>Ultrasound in Medicine and Biology >Adenosine induces dilation of epicardial coronary arteries in mice: relationship between coronary flow velocity reserve and coronary flow reserve in vivo using transthoracic echocardiography.
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Adenosine induces dilation of epicardial coronary arteries in mice: relationship between coronary flow velocity reserve and coronary flow reserve in vivo using transthoracic echocardiography.

机译：腺苷诱导小鼠心外膜冠状动脉扩张：使用经胸超声心动图检查体内冠状动脉血流速度储备与冠状动脉血流储备之间的关系。

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For an accurate estimate of volumetric coronary flow reserve (CFR) using Doppler-assessed flow velocity measurement, it is important to take into consideration potential diameter change during coronary hyperemia. Using ultrasound techniques, left coronary artery (LCA) flow velocity and LCA lumen diameter (LCA(D)) were measured simultaneously for the first time to measure coronary flow during baseline and adenosine-induced hyperemic condition in isoflurane-anesthetized C57BL/6 (n = 38) and in old apolipoprotein E-gene deficient (ApoE(-/-)) mice (n = 44) mice. LCA(D) increased significantly and to a similar extent during adenosine infusion in both groups (3.7 +/- 1.1 %, p < 0.003 for C57BL/6; 4.2 +/- 0.9 %, p < 0.00003 for ApoE(-/-)). Yet, a positive correlation was still found between velocity-based coronary flow velocity reserve (CFVR) and volumetric CFR in both strains (R(2) = 0.77, p < 0.001 for C57BL/6; R(2) = 0.80, p < 0.001 for ApoE(-/-)). Coronary reserve was higher in C57BL/6 mice than in ApoE(-/-) mice (CFR 1.93 +/- 0.17 vs. 1.47 +/- 0.07, p < 0.05; CFVR 1.73 +/- 0.13 vs. 1.28 +/- 0.07, p < 0.01). Thus, ultrasound techniques can be used to measure volumetric flow in the LCA and flow-based CFR measurements of intact, living mice. The positive correlation between CFR and CFVR, together with the lower method variability of the latter, makes CFVR a more robust protocol for assessing mouse in-vivo coronary artery function. Therefore, the CFVR protocol will probably work well in most settings.
机译：为了使用多普勒评估流速测量值准确估算冠状动脉血流储备量（CFR），重要的是要考虑冠状动脉充血期间潜在的直径变化。使用超声技术，首次同时测量左冠状动脉（LCA）流速和LCA管腔直径（LCA（D）），以测量在异氟烷麻醉的C57BL / 6（n = 38）和旧的载脂蛋白E基因缺陷（ApoE（-/-））小鼠（n = 44）小鼠。两组在腺苷输注期间LCA（D）显着增加并且达到相似的程度（C57BL / 6为3.7 +/- 1.1％，p <0.003; ApoE为4.2 +/- 0.9％，p <0.00003（-/-） ）。然而，在两种菌株中，仍发现基于速度的冠状动脉血流速度储备（CFVR）与体积CFR之间存在正相关（R（2）= 0.77，对于C57BL / 6，p <0.001; R（2）= 0.80，p < ApoE（-/-）为0.001。 C57BL / 6小鼠的冠状动脉储备高于ApoE（-/-）小鼠（CFR 1.93 +/- 0.17 vs. 1.47 +/- 0.07，p <0.05; CFVR 1.73 +/- 0.13 vs. 1.28 +/- 0.07 ，p <0.01）。因此，超声技术可用于测量完整存活小鼠的LCA中的体积流量和基于流量的CFR测量。 CFR和CFVR之间的正相关性以及后者的较低方法变异性，使CFVR成为评估小鼠体内冠状动脉功能的更可靠的方案。因此，CFVR协议可能在大多数设置下都能很好地工作。

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