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首页> 外文期刊>Ultrasound in Medicine and Biology >The influence of fragmentation on the acoustic response from shrinking bubbles.
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The influence of fragmentation on the acoustic response from shrinking bubbles.

机译：破碎对气泡收缩引起的声学响应的影响。

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摘要

Bubble disruption is associated with the response of ultrasound contrast agents (UCAs) exposed to high acoustic pressures. This behavior is important for bubble detection techniques as well as flow quantitation and some proposed therapeutic applications. Previous work has measured acoustically the disruption threshold and postdisruption echo from populations of microbubbles. This suggests a model for UCA disruption whereby ultrasound breaks their shell, leaving free gas bubbles. Diffusion of gas causes the bubbles to shrink and, consequently, reduces the measured backscatter echo over time. In this work, similar bubbles containing three different gases were measured and their echo behavior with time compared with a simple simulation based on diffusion of gas out of the bubble. It was found that, in general, the simulations and experiments compared well at low disruption pressures. Incorporating bubble fragmentation in the simulation model brought its results closer to experiment.
机译：气泡破裂与暴露于高声压下的超声造影剂（UCA）的响应有关。此行为对于气泡检测技术以及流量定量和某些建议的治疗应用非常重要。先前的工作从声学上测量了微气泡群体的破坏阈值和破坏后回声。这表明了UCA破坏的模型，超声波破坏了壳，留下了自由的气泡。气体的扩散会导致气泡收缩，从而随着时间的流逝减少测得的反向散射回波。在这项工作中，测量了包含三种不同气体的相似气泡，并与基于气泡从气泡中扩散出来的简单模拟相比较，它们的回声行为随时间变化。人们发现，一般而言，模拟和实验在低破裂压力下进行了比较。将气泡碎片纳入仿真模型可以使其结果更接近实验。

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