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首页> 外文期刊>Ultrasound in Medicine and Biology >Needle size and injection rate impact microbubble contrast agent population.
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Needle size and injection rate impact microbubble contrast agent population.

机译：针头大小和注射速度会影响微泡造影剂的数量。

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摘要

The most common type of ultrasound contrast agents are encapsulated microbubbles, typically 1 to 5 microns in diameter. These microbubbles are injected into the bloodstream to provide image enhancement during an ultrasound examination. Because of their compressibility, these microbubbles are inherently sensitive to changes in pressure. For imaging, this is beneficial in that these microbubbles oscillate in an acoustic field and allow imaging systems to detect their response uniquely from tissue. However, this sensitivity also means that microbubbles can be readily destroyed by significant hydrostatic pressure. Injection of these microbubbles through a small-gauge catheter, such as is sometimes performed in small animal imaging studies, can result in microbubble destruction. In this manuscript, the effects of microbubble injection through catheters of varying diameter are examined. Our results indicate that the concentration and size distribution of microbubbles can be substantially altered in cases of rapid injection through small-gauge needles.
机译：超声造影剂最常见的类型是封装的微气泡，直径通常为1至5微米。这些微气泡被注入到血液中以在超声检查期间提供图像增强。由于它们的可压缩性，这些微气泡固有地对压力变化敏感。对于成像，这是有利的，因为这些微气泡在声场中振荡，并允许成像系统从组织中唯一地检测其响应。但是，这种敏感性也意味着微气泡很容易被明显的静水压力破坏。通过小规格的导管注入这些微气泡（例如在小动物成像研究中有时进行的注射）可能会导致微气泡破坏。在本手稿中，研究了通过不同直径的导管进行微气泡注射的效果。我们的结果表明，在通过小规格针头快速注射的情况下，微气泡的浓度和大小分布可能会发生重大变化。

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