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首页> 外文期刊>Ultrasound in Medicine and Biology >Pre-clinical study of invivo magnetic resonance-guided bubble-enhanced heating in pig liver
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Pre-clinical study of invivo magnetic resonance-guided bubble-enhanced heating in pig liver

机译：猪肝脏体内磁共振引导的气泡增强加热的临床前研究

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Bubble-enhanced heating (BEH) can be exploited to increase heating efficiency in treatment of liver tumors with non-invasive high-intensity focused ultrasound (HIFU). The objectives of this study were: (i) to demonstrate the feasibility of increasing the heating efficiency of sonication exploiting BEH in pig liver invivo using a clinical platform; (ii) to determine the acoustic threshold for such effects with real-time, motion-compensated magnetic resonance-guided thermometry; and (iii) to compare the heating patterns and thermal lesion characteristics resulting from continuous sonication and sonication including a burst pulse. The threshold acoustic power for generation of BEH in pig liver invivo was determined using sonication of 0.5-s duration ("burst pulse") under real-time magnetic resonance thermometry. In a second step, experimental sonication composed of a burst pulse followed by continuous sonication (14.5 s) was compared with conventional sonication (15 s) of identical energy (1.8 kJ). Modification of the heating pattern at the targeted region located at a liver depth between 20 and 25mm required 600-800 acoustic watts. The experimental group exhibited near-spherical heating with 40% mean enhancement of the maximal temperature rise as compared with the conventional sonication group, a mean shift of 7 ± 3.3 mm toward the transducer and reduction of the post-focal temperature increase. Magnetic resonance thermometry can be exploited to control acoustic BEH invivo in the liver. By use of experimental sonication, more efficient heating can be achieved while protecting tissues located beyond the focal point.
机译：可以利用气泡增强加热（BEH）来提高非侵入性高强度聚焦超声（HIFU）在治疗肝肿瘤中的加热效率。这项研究的目的是：（i）通过临床平台证明利用BEH在猪肝体内提高超声处理加热效率的可行性; （ii）通过实时，运动补偿的磁共振引导测温法确定此类效应的声学阈值; （iii）比较由连续超声处理和包括爆裂脉冲的超声处理产生的加热模式和热损伤特性。在实时磁共振测温下使用0.5秒的持续时间（“突发脉冲”）超声测定在猪肝体内产生BEH的阈值声功率。在第二步中，将由突发脉冲组成的实验超声处理，然后进行连续超声处理（14.5 s）与相同能量（1.8 kJ）的常规超声处理（15 s）进行了比较。在位于肝脏深度20至25mm之间的目标区域改变加热方式需要600-800声瓦。实验组显示出接近球形的加热，与常规超声处理组相比，最大温升平均提高了40％，向换能器的平均位移为7±3.3 mm，并且焦点后的温度升高降低了。可以利用磁共振测温法控制肝脏中的声BEH体内。通过使用实验超声，可以在保护位于焦点之外的组织的同时实现更有效的加热。

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