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首页> 外文期刊>Ultrasound in Medicine and Biology >Flow Quantification with Nakagami Parametric Imaging for Suppressing Contrast Microbubbles Attenuation
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Flow Quantification with Nakagami Parametric Imaging for Suppressing Contrast Microbubbles Attenuation

机译：使用Nakagami参数成像进行流量量化以抑制对比微气泡衰减

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Flow quantification with contrast-enhanced ultrasound is still limited by the effects of contrast microbubble attenuation. Nakagami parametric imaging (NPI) based on the m parameter, which is related to the statistical property of echo envelope, is implemented to suppress contrast attenuation. Flow velocity (FV) and volumetric flow rate (VFR) are estimated through the least square fitting of burst depletion kinetic model to time m parameter curves (TMCs). A non-recirculating flow phantom is imaged as contrast microbubbles are infused at 10, 15, 20, 25, and 30 mL/min. Contrast microbubbles with two different concentrations are used to generate variations of contrast microbubble attenuation. The results suggest that 4 × 4 mm2 is the optimal size of a sliding window of NPI for flow quantification under current experiment condition. At a lower microbubble concentration, the FV calculated from TMCs correlates strongly with actual FV in both unattenuated (R2 = 0.97; p 0.01) and attenuated regions (R2 = 0.92; p 0.01) within phantom. And there is a strong correlation (R2 = 0.98; p 0.01; slope = 0.96; intercept = 0.68) between VFR calculated from TMCs and actual VFR within the whole phantom. Similar results are obtained at higher microbubble concentrations. Compared with conventional ultrasound imaging that is intensity dependent, NPI achieves better performance on flow quantification in the presence of contrast microbubble attenuation.
机译：造影剂增强超声的流量量化仍然受到造影剂微泡衰减的​​影响。实现基于m参数的Nakagami参数成像（NPI）与回波包络的统计特性有关，以抑制对比度衰减。流速（FV）和体积流速（VFR）是通过突发消耗动力学模型与时间m参数曲线（TMC）的最小二乘拟合估算的。当以10、15、20、25和30 mL / min的速度注入对比微气泡时，对非循环流动体模成像。具有两种不同浓度的对比微气泡用于生成对比微气泡衰减的变化。结果表明，在当前实验条件下，用于流量定量的NPI滑动窗口的最佳尺寸为4×4 mm2。在较低的微气泡浓度下，从TMC计算出的FV与体模中未衰减的区域（R2 = 0.97; p <0.01）和衰减区域（R2 = 0.92; p <0.01）中的实际FV密切相关。从TMC计算的VFR与整个模型中的实际VFR之间存在很强的相关性（R2 = 0.98; p <0.01;斜率= 0.96;截距= 0.68）。在较高的微气泡浓度下可获得类似的结果。与强度相关的常规超声成像相比，在存在造影剂微气泡衰减的情况下，NPI在流量定量方面具有更好的性能。

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