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首页> 外文期刊>Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology >Ultrasound dating at 12-14 or 15-20 weeks of gestation? A prospective cross-validation of established dating formulae in a population of in-vitro fertilized pregnancies randomized to early or late dating scan.
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Ultrasound dating at 12-14 or 15-20 weeks of gestation? A prospective cross-validation of established dating formulae in a population of in-vitro fertilized pregnancies randomized to early or late dating scan.

机译：妊娠12-14或15-20周的超声约会？在随机进行早期或晚期约会扫描的体外受精妊娠人群中，已建立的约会公式的前瞻性交叉验证。

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摘要

OBJECTIVES: To determine the accuracy of established ultrasound dating formulae when used at 12-14 and 15-20 gestational weeks. METHODS: A total of 363 singleton pregnancies conceived after in-vitro fertilization (IVF) and randomized to a dating scan at 12-14 or 15-20 gestational weeks were studied. 'True' gestational age was calculated on the basis of the day of oocyte retrieval and was compared to gestational age calculated on the basis of seven dating formulae including the fetal biparietal diameter (BPD) and three dating formulae including BPD and fetal femur length (FL). The mean of the differences between estimated and true gestational age (systematic measurement error) and their SD (random measurement error) were calculated for each formula. RESULTS: Three formulae showed systematic errors of less than -0.7 days at both early and late scanning. Two formulae overestimated gestational age at both early and late scanning by 5.7 and 3.1 vs. 2.3 and 2.8 days, respectively, while five formulae manifested very different systematic errors at early and late scanning. The formulae used for clinical management underestimated gestational age by a mean of 3 days when dating was performed at 12-14 weeks, and by a mean of 0.8 days when dating was done at 15-20 weeks. The random error was on average 1 day less when the scan was carried out early (2 vs. 3 days; P < 0.0005). Mean true gestational age at delivery in IVF pregnancies with spontaneous start of labor was 279 days (SD 12.9); excluding preterm deliveries it was 281 days (SD 8.1). CONCLUSIONS: Ultrasound dating formulae originally intended for use in the middle of the second trimester do not necessarily perform well when used for dating earlier in gestation. The systematic and random error of any dating formula must be assessed for the gestational age interval in which the formula is intended to be used.
机译：目的：确定在妊娠12-14和15-20周时使用的超声测年公式的准确性。方法：对总共363例单胎妊娠进行了体外受精（IVF），并在妊娠第12-14或15-20周随机进行了约会扫描。根据卵母细胞取回日计算“正确”胎龄，并将其与根据包括胎儿双顶壁直径（BPD）在内的七个测年公式和包括BPD和胎儿股骨长（FL）的三个测年公式计算的胎龄进行比较）。为每个公式计算出估计胎龄和真实胎龄之间的差异的平均值（系统测量误差）和其SD（随机测量误差）。结果：三个公式显示在早期和晚期扫描时系统误差均小于-0.7天。在早期和晚期扫描时，两个公式分别高估了胎龄5.7和3.1与2.3和2.8天，而五个公式在早期和晚期扫描时表现出非常不同的系统误差。用于临床管理的公式在12-14周进行约会时平均低估了胎龄3天，而在15-20周进行约会时平均低估了0.8天。早期进行扫描时，随机误差平均要少1天（2天比3天; P <0.0005）。 IVF妊娠中自发分娩的平均实际胎龄为279天（SD 12.9）;排除早产，这是281天（SD 8.1）。结论：最初用于妊娠中期的超声测年公式在妊娠早期用于测年时不一定表现良好。任何约会公式的系统误差和随机误差必须在打算使用该公式的胎龄间隔内进行评估。

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