1,4-pentenyne as a five-carbon synthon for efficient and selective syntheses of natural products containing 2,4-dimethyl-1-penten-1,5-ylidene and related moieties by means of Zr-catalyzed carboalumination of alkynes and alkenes

Zhu GG; Negishi EI

首页> 外文期刊>Chemistry: A European journal >1,4-pentenyne as a five-carbon synthon for efficient and selective syntheses of natural products containing 2,4-dimethyl-1-penten-1,5-ylidene and related moieties by means of Zr-catalyzed carboalumination of alkynes and alkenes

【24h】

1,4-pentenyne as a five-carbon synthon for efficient and selective syntheses of natural products containing 2,4-dimethyl-1-penten-1,5-ylidene and related moieties by means of Zr-catalyzed carboalumination of alkynes and alkenes

机译：1,4-戊烯作为五碳合成子，用于通过Zr催化炔烃和烯烃的碳铝催化有效和选择性地合成包含2,4-二甲基-1-戊烯-1,5-亚烷基和相关部分的天然产物

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Two highly efficient protocols for enantioselective synthesis of 2,4-dimethyl-1-penten-1,5-ylidene derivatives involve the combined use of the Zr-catalyzed methylalumination of alkynes (ZMA) and the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA). The ZMA/ZACA protocol has been applied to the synthesis of a nafuredin intermediate 14 and a potential intermediate 18 for milbemycin beta(3), while the ZACA/ZMA protocol has been applied to the synthesis of a (-)-bafilomycin A(1) intermediate 25.

机译：对映选择性合成2,4-二甲基-1-戊烯-1,5-亚烷基衍生物的两个高效方案涉及Zr催化的炔烃甲基铝化（ZMA）和Zr催化的烯烃不对称碳铝化（ZACA）的组合使用）。 ZMA / ZACA协议已被用于合成米尔布霉素beta（3）的那富瑞丁中间体14和潜在的中间体18，而ZACA / ZMA协议已被应用于合成（-）-bafilomycin A（1））中级25。

著录项

来源
《Chemistry: A European journal》 |2008年第1期|共8页
作者
Zhu GG; Negishi EI;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
pentenyne; asymmetric synthesis; catalysis; natural products; zirconium; ASYMMETRIC CARBOALUMINATION; BAFILOMYCIN A(1); STEREOSELECTIVE-SYNTHESIS; ALDOL REACTIONS; IMMUNOSUPPRESSANT (-)-FK-506; NEUTRAL SPHINGOMYELINASE; MONOSUBSTITUTED ALKENES; ABSOLUTE-CONFIGURATION; STRUCTURAL ELUCIDATION; (amp; )-MILBEMYCIN BETA-3;

机译：戊烯;不对称合成;催化;天然产物;锆;不对称碳铝化;BAMOLOMYCIN A（1）;立体选择性合成;ALDOL反应;免疫抑制剂（-）-FK-506;中性神经肽酶;单取代的链烯基;结构化;AB （＆）-米尔贝霉素BETA-3;

相似文献

外文文献
中文文献
专利

1. 1,4-pentenyne as a five-carbon synthon for efficient and selective syntheses of natural products containing 2,4-dimethyl-1-penten-1,5-ylidene and related moieties by means of Zr-catalyzed carboalumination of alkynes and alkenes [J] . Zhu GG, Negishi EI Chemistry: A European journal . 2008,第1期

机译：1,4-戊烯作为五碳合成子，用于通过Zr催化炔烃和烯烃的碳铝催化有效和选择性地合成包含2,4-二甲基-1-戊烯-1,5-亚烷基和相关部分的天然产物
2. A Novel,Selective,and Efficient Route to Carotenoids and related Natural Products via Zr-Catalyzed Carboalumination and Pd- and Zn-catalyzed Cross Coupling [J] . Fanxing Zeng, Ei-ichi Negishi Organic letters . 2001,第5期

机译：一种通过Zr催化的碳铝络合以及Pd和Zn催化的交叉偶联制得类胡萝卜素及相关天然产物的新颖，高效的方法
3. Efficient and selective synthesis of (S,R,R,S,R,S)-4,6,8,10,16,18-hexamethyl-docosane via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction) [J] . Zhu GG, Liang B, Negishi EI Organic letters . 2008,第6期

机译：通过Zr催化的烯烃不对称碳铝高效且选择性地合成（S，R，R，S，R，S）-4,6,8,10,16,18-六甲基二十二烷（ZACA反应）
4. Electrocatalytic Semihydrogenation of Alkynes to Z-Alkenes Using a Proton Exchange Membrane Reactor: Influence of Catalyst Materials on Product Selectivity and Reaction Rate [C] . Mahito Atobe, Shuji Nogami, Juri Minoshima, Meeting of the Electrochemical Society;International Meeting on Chemical Sensors . 2020

机译：使用质子交换膜反应器的炔烃对Z-烯烃的电催化半过滤器：催化剂材料对产物选择性和反应速率的影响
5. Palladium-catalyzed Negishi coupling and zirconium -catalyzed asymmetric carboalumination of alkenes (ZACA): Powerful tools in the synthesis of natural products [D] . Huang, Zhihong 2008

机译：钯催化的Negishi偶联和锆催化的烯烃不对称碳铝化（ZACA）：合成天然产物的有力工具
6. Efficient and Stereoselective Synthesis of Yellow Scale Pheromone via Alkyne Haloboration Zr-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA Reaction) and Pd-Catalyzed Tandem Negishi Coupling [O] . Zhaoqing Xu, Ei-ichi Negishi* -1

机译：通过炔烃卤化Zr催化的烯烃不对称碳铝化（ZACA反应）和Pd催化的串联Negishi偶联高效且立体选择性地合成黄色鳞状信息素。
7. Efficient and Selective Synthesis of (S,R,R,S,R,S)-4,6,8,10,16,18-Hexamethyldocosane via Zr-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA Reaction) [O] . -1

机译：高效且选择性合成（S，R，R，S，R，S）-4,6,8,10,16,18-六甲基二烷烷通过Zr催化的烯烃（Zaca反应）

1,4-pentenyne as a five-carbon synthon for efficient and selective syntheses of natural products containing 2,4-dimethyl-1-penten-1,5-ylidene and related moieties by means of Zr-catalyzed carboalumination of alkynes and alkenes

摘要

著录项

相似文献

相关主题

期刊订阅