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首页> 外文期刊>Chemistry: A European journal >Four generations of water-soluble dendrimers with 9 to 243 benzoate tethers: Synthesis and dendritic effects on their ion pairing with acetylcholine, benzyltriethylammonium, and dopamine in water
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Four generations of water-soluble dendrimers with 9 to 243 benzoate tethers: Synthesis and dendritic effects on their ion pairing with acetylcholine, benzyltriethylammonium, and dopamine in water

机译：具有9至243条苯甲酸酯系链的四代水溶性树状聚合物：与乙酰胆碱，苄基三乙基铵和多巴胺在水中的离子配对的合成和树状作用

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摘要

Water-soluble benzoate-terminated dendrimers of four generations (from G(0) with 9 branches to G(3) with 243 branches) were synthesized and fully characterized. They form water-soluble assemblies by ion-pairing interactions with three cations of medicinal interest (acetylcoline, benzyl-triethylammonium, and dopamine), which were characterized and investigated by H-1 NMR spectroscopy, where-as such interactions do not provoke any significant shift of H-1 NMR signals with the monomeric benzoate anion. The calculated association constants confirm that the dendritic carboxylate termini reversibly form ion pairs aggregates. Diffusion coefficients hydrodynamic diameters of the and and dendrimers, as well as changes thereof on interaction with the cations, were evaluated by DOSY experiments. The lack of increase of dendrimer size on addition of the cations and the upfield shifts of the H-1 NMR signals of the cation indicate encapsulation within the hydrophobic dendrimer interiors together with probable backfolding of the benzoate termini.
机译：合成并充分表征了四代水溶性苯甲酸酯封端的树枝状聚合物（从具有9个分支的G（0）到具有243个分支的G（3））。它们通过与三个具有药用价值的阳离子（乙酰基脯氨酸，苄基三乙基铵和多巴胺）进行离子配对相互作用而形成水溶性组装体，并通过H-1 NMR光谱对其进行了表征和研究，其中，这种相互作用不会引起任何明显的变化。 H-1 NMR信号与单体苯甲酸酯阴离子的平移。计算的缔合常数证实了树状羧酸盐末端可逆地形成离子对聚集体。通过DOSY实验评估了和和树枝状聚合物的扩散系数的流体力学直径，以及它们与阳离子相互作用时的变化。在添加阳离子时树枝状聚合物尺寸的增加不足以及阳离子的H-1 NMR信号的高场偏移表明，封装在疏水性树枝状聚合物内部以及苯甲酸酯末端可能发生的折叠。

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