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首页> 外文期刊>Ultrastructural pathology >Ultrastructural changes in prostate cells during hormone-induced canine prostatic hyperplasia.
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Ultrastructural changes in prostate cells during hormone-induced canine prostatic hyperplasia.

机译：激素诱导的犬前列腺增生过程中前列腺细胞的超微结构变化。

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Benign prostatic hyperplasia is a prevalent disease that has received relatively little attention in spite of its morbidity and remarkable social impact. There are few animal models of prostatic hyperplasia. The dog is the only species, along with humans, in which prostatic hyperplasia develops spontaneously and almost universally with age. The aim of the present study has been to compare the ultrastructural findings in a model of experimentally induced canine prostatic hyperplasia with those of the spontaneously developed changes in untreated dogs. An experimental group of 5 male beagle dogs were castrated and treated with combined steroids (3 weekly doses for over 30 weeks). Prostate samples were surgically obtained every 42 days (experimental stages 0 through 6). The control group consisted of 3 noncastrated dogs that were treated with vehicle and in which samples were taken only at stages 0, 1, 4, and 6. Changes in the control groups were similar but of lower intensity compared to those of the experimental groups. In luminal cells, crowding with papillary projections, prominent, branching microvilli, and abundant, often compartmentalized granules were observed. The most striking change was the previously unreported finding of caveolae in basal cells. They were mostly located in the basal aspect of basal cells and were more prominent in the experimental group and in advanced stages of treatment. These ultrastructural findings have not been previously reported in canine or human prostatic hyperplasia and merit further research. The model of experimentally induced canine prostatic hyperplasia provides an adequate setting for the understanding of this disease.
机译：良性前列腺增生是一种普遍的疾病，尽管其发病率高和社会影响大，却很少受到关注。前列腺增生的动物模型很少。与人类一样，狗是唯一的物种，其中前列腺增生会随着年龄的增长自发且几乎普遍出现。本研究的目的是将实验诱导的犬前列腺增生模型中的超微结构发现与未经治疗的狗自发发展的变化进行比较。实验组5只雄性比格犬被去势并用类固醇联合治疗（3周剂量，持续30周以上）。每42天（实验阶段0到6）通过手术获得前列腺样品。对照组由3只未cast割的犬组成，这些犬用媒介物治疗，并且仅在0、1、4和6阶段取样。对照组的变化与实验组相似，但强度较低。在腔细胞中，观察到挤满了乳头状突起，突出的分支微绒毛和丰富的，经常是分隔的颗粒。最显着的变化是先前未报道的基底细胞中小窝的发现。它们主要位于基底细胞的基底部分，在实验组和晚期治疗中更为突出。这些超微结构的发现以前在犬或人类前列腺增生中尚未报道过，值得进一步研究。实验性诱导的犬前列腺增生模型为了解这种疾病提供了充分的条件。

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