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首页> 外文期刊>Chemistry: A European journal >beta-Cyclodextrin-Appended Giant Amphiphile: Aggregation to Vesicle Polymersomes and Immobilisation of Enzymes
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beta-Cyclodextrin-Appended Giant Amphiphile: Aggregation to Vesicle Polymersomes and Immobilisation of Enzymes

机译：β-环糊精附加的巨型两亲物：囊泡聚合物囊泡的聚集和酶的固定化。

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摘要

A giant amphiphile consisting of polystyrene end-capped with permethylated P-cyclodextrin was synthesised and found to form vesicular structures when injected as a solution in THF into water. The ability of the cyclodextrins on the surface of the polymersomes to form inclusion complexes with hydrophobic compounds was tested by carrying out a competition experiment with a fluorescent probe sensitive to the polarity of the surrounding medium. It was found that l-adamantol can displace the fluorescent probe from the cavities of the cyclodextrin moieties of the polymersomes. The recognition of molecules by cell membranes in nature is often based on interactions with specific membrane receptors. To mimic this behaviour, the enzyme horseradish peroxidase was modified with adamantane groups through a poly(ethylene glycol) spacer and its interaction with the polymersomes was investigated. It was established that the presence of adamantane moieties on each enzyme allowed a host-guest interaction with the multifunctional surface of the polymersomes.
机译：合成了由封端有全甲基化的P-环糊精的聚苯乙烯组成的巨型两亲物，当以THF溶液形式注入水中时，发现其形成了囊状结构。通过用对周围介质的极性敏感的荧光探针进行竞争实验，测试了聚合物囊泡表面上环糊精与疏水化合物形成包合物的能力。已经发现1-金刚烷酚可以从多聚体的环糊精部分的腔中置换荧光探针。自然界中细胞膜对分子的识别通常基于与特定膜受体的相互作用。为了模仿这种行为，辣根过氧化物酶通过金刚烷基团通过聚乙二醇间隔基进行修饰，并研究了其与聚合物囊泡的相互作用。已经确定，每种酶上金刚烷部分的存在允许宿主-客体与聚合物小体的多功能表面相互作用。

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