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首页> 外文期刊>Chemistry: A European journal >DNA-Assisted Self-Assembly of Pyrene Foldamers
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DNA-Assisted Self-Assembly of Pyrene Foldamers

机译：脱氧核糖核酸折叠分子的DNA辅助自组装

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摘要

The self-organization of oligopyrene foldamers is described. Biand tri-segmental oligomers composed of nucleotides and non-nucleosidic, achiral pyrene monomers form doublestranded helical structures, as shown by absorbance, fluorescence, and CD spectroscopy. The mixed nature of alternating aromatic and phosphate groups ensures water solubility which, in turn, favors folding of the aromatic units. Pyrene molecules also assemble though interstrand stacking interactions. Structural organization of the pyrene units is an intrinsic property of the oligoaryl part and takes place independently from the sequence of the attached DNA. Chirality transfer from DNA to the pyrene segment leads to formation of a double helix, in which neighboring pyrene units are, in the present case, twisted in a right-handed manner. Pyrene helicity is most pronounced in a bi-segmental chimera, in which a DNA stem is present only at one end of the pyrene section.
机译：描述了低py折叠剂的自组织。由核苷酸和非核苷，非手性pyr单体组成的双三段低聚物形成双链螺旋结构，如吸光度，荧光和CD光谱所示。交替的芳族基团和磷酸酯基团的混合性质确保了水溶性，这又有利于芳族单元的折叠。 molecules分子也通过链间堆叠相互作用组装。 units单元的结构组织是低聚芳基部分的固有特性，并且独立于附着的DNA序列进行。从DNA到to的手性转移导致形成双螺旋，其中在当前情况下，相邻的units单元以右旋方式扭曲。 a螺旋在双节嵌合体中最为明显，其中DNA茎仅存在于section部分的一端。

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