• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAS) as turn mimetics
【24h】

Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAS) as turn mimetics

机译：含有顺式和反式吗啉氨基酸（MAAS）作为仿制品的Gramicidin S衍生物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The cyclic decapeptide gramicidin S (GS) was used as a model for the evaluation of four turn mimetics. For this purpose, one of the D-Phe-Pro two-residue turn motifs in the rigid cyclic β-hairp0in structure of GS was replaced with morpholine amino acids (MAA 2-5), differing in stereochemistry and length of the side-chain. The conformational properties of the thus obtained GS analogues (6-9) was assessed by using NMR spectroscopy and X-ray crystallography, and correlated with their biological properties (antimicrobial and hemolytic activity). We show that compound 8, containing the dipeptide isostere trans-MAA 4, has an apparent high structural resemblance with GS and that its antibacterial activity against a panel of Gram positive and -negative bacterial strains is better than the derivatives 6, 7 and 9.
机译：环状十肽短杆菌肽S（GS）被用作评估四轮模拟物的模型。为此，GS的刚性环状β-hairp0in结构中的D-Phe-Pro两残基转基元之一被吗啉氨基酸（MAA 2-5）取代，其立体化学和侧链长度不同。通过使用NMR光谱法和X射线晶体学评估由此获得的GS类似物（6-9）的构象性质，并将其与它们的生物学性质（抗微生物和溶血活性）相关。我们显示包含二肽等排体反式MAA 4的化合物8与GS具有明显的高结构相似性，并且其对一组革兰氏阳性和阴性细菌菌株的抗菌活性优于衍生物6、7和9。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号