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首页> 外文期刊>Undersea and Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society >Oral administration of lactulose: a novel therapy for acute carbon monoxide poisoning via increasing intestinal hydrogen production
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Oral administration of lactulose: a novel therapy for acute carbon monoxide poisoning via increasing intestinal hydrogen production

机译：乳果糖的口服给药：通过增加肠道氢气产生来治疗急性一氧化碳中毒的新疗法

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摘要

It has been known that the pathophysiology of carbon monoxide (CO) poisoning is related to hypoxia, the increased production of reactive oxygen species (ROS) and oxidative stress. Studies have shown that the novel, safe and effective free radical scavenger, hydrogen, has neuroprotective effects in both acute CO poisoning and delayed neuropsychological sequelae in CO poisoning. Orally administered lactulose, which may be used by some intestinal bacteria as a food source to produce endogenous hydrogen, can ameliorate oxidative stress. Based on the available findings, we hypothesize that oral administration of lactulose may be a novel therapy for acute CO poisoning via increasing intestinal hydrogen production.
机译：众所周知，一氧化碳（CO）中毒的病理生理与缺氧，活性氧（ROS）的产生增加和氧化应激有关。研究表明，新颖，安全，有效的自由基清除剂氢在急性CO中毒和延迟的CO中毒神经心理后遗症中均具有神经保护作用。口服给予的乳果糖可被某些肠道细菌用作产生内源氢的食物来源，可以减轻氧化应激。基于现有的发现，我们假设口服乳果糖可能是通过增加肠道氢产生来治疗急性CO中毒的新型疗法。

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