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首页> 外文期刊>Psychoneuroendocrinology: An International Journal >Comfort food is comforting to those most stressed: evidence of the chronic stress response network in high stress women.
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Comfort food is comforting to those most stressed: evidence of the chronic stress response network in high stress women.

机译：舒适食品能让那些压力最大的人感到舒适：高压力女性的慢性压力反应网络的证据。

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摘要

Chronically stressed rodents who are allowed to eat calorie-dense "comfort" food develop greater mesenteric fat, which in turn dampens hypothalamic-pituitary-adrenocortical (HPA) axis activity. We tested whether similar relations exist in humans, at least cross-sectionally. Fifty-nine healthy premenopausal women were exposed to a standard laboratory stressor to examine HPA response to acute stress and underwent diurnal saliva sampling for basal cortisol and response to dexamethasone administration. Based on perceived stress scores, women were divided into extreme quartiles of low versus high stress categories. We found as hypothesized that the high stress group had significantly greater BMI and sagittal diameter, and reported greater emotional eating. In response to acute lab stressor, the high stress group showed a blunted cortisol response, lower diurnal cortisol levels, and greater suppression in response to dexamethasone. These cross-sectional findings support the animal model, which suggests that long-term adaptation to chronic stress in the face of dense calories result in greater visceral fat accumulation (via ingestion of calorie-dense food), which in turn modulates HPA axis response, resulting in lower cortisol levels.
机译：允许长期进食高热量“舒适”食物的慢性压力啮齿动物会产生更大的肠系膜脂肪，从而降低下丘脑-垂体-肾上腺皮质激素（HPA）轴的活动。我们测试了人类是否存在类似的关系，至少是在横截面上。 59名健康的绝经前妇女暴露于标准实验室应激源下，以检查其对急性应激的HPA反应，并通过昼夜唾液取样测定基础皮质醇和地塞米松的反应。根据感知的压力得分，将女性分为低压力类别和高压力类别的极端四分位数。作为假设，我们发现高压力组的BMI和矢状面直径明显更大，并且报告了较高的情绪饮食。在对急性实验室应激源的反应中，高压力组显示皮质醇反应减弱，昼夜皮质醇水平降低，对地塞米松的抑制作用更大。这些横截面的发现支持了该动物模型，该模型表明，长期面对密度高的卡路里适应慢性压力会导致内脏脂肪积累（通过摄入高密度食物）更大，进而调节HPA轴反应，导致皮质醇水平降低。

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