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首页> 外文期刊>Psychoneuroendocrinology: An International Journal >Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF
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Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF

机译：试管婴儿妇女头发和唾液皮质醇与妊娠的关系

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Evidence for an association between cortisol and clinical pregnancy in women undergoing In Vitro Fertilisation (IVF) is mixed with previous studies relying exclusively on short term measures of cortisol in blood, saliva, urine, and/or follicular fluid. Hair sampling allows analysis of systemic levels of cortisol over the preceding 3-6 months. The present study sought to explore the relationship between cortisol and clinical pregnancy outcome in women undergoing IVF utilising multiple indices of cortisol derived from both saliva and hair measured prior to commencing gonadotrophin treatment. A total of 135 women (mean age 34.5 SD+/-4.8) were recruited from an English fertility clinic (December 2012-April 2014) 60% of whom became pregnant (n=81). Salivary cortisol data were obtained over two days: upon awakening, 30 min post awakening, and at 22:00. A subsample (n=88) of the women providing salivary samples were approached consecutively to provide hair samples for the measurement of cortisol. Independent Logistic regression analyses revealed that salivary cortisol measures including cortisol awakening response (CAR) (p=0.485), area under the curve with respect to ground (AUCg) (p=0.527), area under the curve with respect to increase (AUCi) (p=0.731) and diurnal slope (p=0.889) did not predict clinical pregnancy. In contrast, hair cortisol concentrations significantly predicted clinical pregnancy (p=0.017). Associations between hair cortisol and clinical pregnancy remained when controlling for accumulations of salivary cortisol (p=0.034) accounting for 26.7% of the variance in pregnancy outcome.
机译：接受体外受精（IVF）的女性的皮质醇与临床妊娠之间存在关联的证据与以前的研究完全混合在一起，以前的研究仅依赖于血液，唾液，尿液和/或卵泡液中皮质醇的短期测量。头发采样可以分析前3-6个月的全身皮质醇水平。本研究试图通过在开始促性腺激素治疗之前测量唾液和头发的多种皮质醇指标，探索接受IVF的妇女皮质醇与临床妊娠结局之间的关系。从英国生育诊所（2012年12月至2014年4月）招募了135名妇女（平均年龄34.5 SD +/- 4.8），其中60％怀孕（n = 81）。在两天内获得唾液皮质醇数据：清醒时，清醒后30分钟和22:00。连续抽取提供唾液样本的妇女的子样本（n = 88）以提供用于测量皮质醇的头发样本。独立Logistic回归分析显示，唾液皮质醇测量值包括皮质醇觉醒反应（CAR）（p = 0.485），相对于地面的曲线下面积（AUCg）（p = 0.527），相对于增加的曲线下面积（AUCi） （p = 0.731）和日斜率（p = 0.889）不能预测临床妊娠。相反，头发中的皮质醇浓度显着预测了临床妊娠（p = 0.017）。当控制唾液皮质醇的积累（p = 0.034）时，头发皮质醇与临床妊娠之间的关联仍然存在（占妊娠结局差异的26.7％）。

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