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首页> 外文期刊>Chemistry: A European journal >Signal-Off and Signal-On Design for a Label-Free Aptasensor Based on Target-Induced Self-Assembly and Abasic-Site-Binding Ligands
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Signal-Off and Signal-On Design for a Label-Free Aptasensor Based on Target-Induced Self-Assembly and Abasic-Site-Binding Ligands

机译：基于目标诱导的自组装和无碱基结合配体的无标签自适应传感器的信号关闭和信号打开设计

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摘要

Aptamers are short oligonucleotides that have high affini-ty and specificity toward their targets.~[1]Since aptamers pos-sess considerable advantages, such as adaptability to varioustargets, versatility in labeling, and chemical simplicity, theyhave become increasingly important molecular tools for bio-assays, diagnostics, and therapeutics.~[2]Aptamers often un-dergo significant conformational changes upon target bind-ing, and many sensing strategies have been proposed todetect targets based on these conformational changes. Asone of the approaches for the development of aptamer-based sensors (aptasensors), target-induced self-assembly ofaptamer fragments, has been reported to detect targets with-out significant perturbation of the ligand-binding abilities in-herent to the original aptamers.
机译：适体是短的寡核苷酸，对它们的靶标具有高亲和力和特异性。〜[1]由于适体具有相当大的优势，例如对各种靶标的适应性，标记的通用性和化学简便性，它们已成为越来越重要的生物分子工具[2]适体通常会在结合靶标后发生显着的构象变化，并且已提出了许多基于这些构象变化的检测策略来检测靶标。作为开发基于适体的传感器（aptasensors）的方法之一，据报道靶标诱导的自适体片段的自组装可检测靶标，而对原始适体固有的配体结合能力没有明显的干扰。

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