Crystallization-Induced Diastereoselection: Asymemtric Synthesis of Substance P Inhibitors

Philip J. Pye; Kai Rossen; Steven A. Weissman; Ashok Maliakal; Robert A. Reamer; Rcihard Ball; Nancy N. Tsou; R.P. Volante; Paul J. Reider

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Crystallization-Induced Diastereoselection: Asymemtric Synthesis of Substance P Inhibitors

机译：结晶诱导的非对映体选择：P物质抑制剂的不对称合成

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摘要

A novel three-component condensation followed by a crystallizationinduced asymmetric transformation is used to build this key substance P inhibitor intermediate in a short synthetic sequence.

机译：一种新颖的三组分缩合反应，然后进行结晶诱导的不对称转化，可用于以较短的合成顺序构建该关键物质P抑制剂中间体。

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来源
《Chemistry: A European journal》 |2002年第6期|共5页
作者
Philip J. Pye; Kai Rossen; Steven A. Weissman; Ashok Maliakal; Robert A. Reamer; Rcihard Ball; Nancy N. Tsou; R.P. Volante; Paul J. Reider;
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正文语种 eng
中图分类化学;应用化学;
关键词
asymmetric synthesis; crystalliation-driven transformation; dihydroxylation; Mitsunobureaction; substance P inhibitors;

机译：不对称合成;结晶驱动转变;二羟基化;三不纯作用;P物质抑制剂;

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专利

1. Crystallization-Induced Diastereoselection: Asymemtric Synthesis of Substance P Inhibitors [J] . Philip J. Pye, Kai Rossen, Steven A. Weissman, Chemistry: A European journal . 2002,第6期

机译：结晶诱导的非对映体选择：P物质抑制剂的不对称合成
2. Crystallization-Induced Dynamic Resolution toward the Synthesis of (S)-7-Amino-5H,7H-dibenzo[b,d]-azepin-6-one: An Important Scaffold for gamma-Secretase Inhibitors [J] . Karmakar Sukhen, Byri Vijay, Gavai Ashvinikumar V., Organic process research & development . 2016,第10期

机译：结晶诱导的动态拆分合成（S）-7-氨基-5H，7H-二苯并[b，d]-氮杂-6-一个：γ-分泌酶抑制剂的重要支架。
3. A novel crystallization-induced diastereomeric transformation based on a reversible carbon-sulfur bond formation. Application to the synthesis of a gamma-secretase inhibitor [J] . Davies AJ, Scott JP, Bishop BC, The Journal of Organic Chemistry . 2007,第13期

机译：基于可逆的碳硫键形成的新型结晶诱导的非对映异构转变。在合成γ-分泌酶抑制剂中的应用
4. Synthesis and π-Facial Diastereoselection of Heterocyclic Cage Compounds [C] . Hui-Chang Lin International symposium for Chinese organic chemists . 2000

机译：杂环笼子化合物的合成与π面部偏心选择
5. The Design and Synthesis of Novel Proteasome Inhibitors: Studies on the Synthesis of Nagelamide M and Analogs, the Synthesis of Rapamycin Based Proteasome Inhibitors, and the Synthesis of TCH Based Molecular Probes for Binding Site Determination. [D] . Giletto, Matthew Basil. 2017

机译：新型蛋白酶体抑制剂的设计与合成：Nagelamide M和类似物的合成，雷帕霉素基蛋白酶体抑制剂的合成以及TCH基分子探针的结合位点测定的研究。
6. Substance P Inhibits the Collagen Synthesis of Rat Myocardial Fibroblasts Induced by Ang II [O] . Zhiyong Yang, Xinzhong Zhang, Naipeng Guo, 2016

机译：P物质抑制Ang II诱导的大鼠心肌成纤维细胞胶原合成
7. A Novel Crystallization-Induced Diastereomeric Transformation Based on a Reversible Carbon-Sulfur Bond Formation. Application to the Synthesis of a g-Secretase Inhibitor [O] . -1

机译：基于可逆碳 - 硫键形成的新型结晶诱导的非对映异构化转化。在合成G分泌酶抑制剂的应用

Crystallization-Induced Diastereoselection: Asymemtric Synthesis of Substance P Inhibitors

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