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首页> 外文期刊>Urological Science >Benefits and concerns of early adjuvant radiotherapy for prostate cancer with pathological adverse tumor characteristics
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Benefits and concerns of early adjuvant radiotherapy for prostate cancer with pathological adverse tumor characteristics

机译：早期辅助放疗对具有病理不良肿瘤特征的前列腺癌的益处和关注

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This article is a comment on the article "BoHan et al, The Results of Early or Delayed Adjuvant Radiotherapy for Prostate Cancer with Pathological Adverse Tumor Characteristics: A Single Institute Experience."Surgical removal of the prostate and seminal vesicles has a high chance of cure when prostate cancer is confined to the prostate. High-risk features, such as the presence of extraprostatic extension (Stage pT3a or pT3b) and/or positive surgical margins found at the time of surgery increase the risk of the cancer recurring. Despite a stage shift to earlier cancer stages and lower tumor volumes for prostate cancer, pathologically advanced disease is detected at radical prostatectomy (RP) in 38-52% of patients.The current study enrolled 53 men with prostate cancer of pathological adverse characteristics who had undergone RP, and compared outcomes of early (< 3 months) and delayed (3-12 months) adjuvant radiotherapy (ART) after RP. The results showed trends of early ART improving 5-year biochemical-free survival, less salvage hormonal therapy, and more urethral stricture; however, there were no statistically significant differences.
机译：本文是对“ BoHan等人，具有病理学不良肿瘤特征的前列腺癌的早期或延迟辅助放疗的结果：单一的研究机构经验”的评论。当前列腺癌局限于前列腺癌时。高风险特征，例如前列腺外延伸的存在（阶段pT3a或pT3b）和/或在手术时发现的手术切缘阳性，会增加癌症复发的风险。尽管前列腺癌已转移到癌症的早期阶段并降低了肿瘤的体积，但在38-52％的患者中，在根治性前列腺切除术（RP）上仍检测到病理学上处于晚期的疾病。本研究招募了53名患有病理学不良特征的前列腺癌男性进行RP，并比较RP之后早期（<3个月）和延迟（3-12个月）辅助放疗（ART）的结果。结果表明，早期抗逆转录病毒疗法可提高5年无生化生存率，减少打捞激素疗法和增加尿道狭窄的趋势。但是，没有统计学上的显着差异。

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