An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases

Kim T.-I.; Jeong M.S.; Chung S.J.; Kim Y.

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An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases

机译：基于亚氨基香豆素的荧光探针，可选择性检测双特异性蛋白酪氨酸磷酸酶

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(Figure Presented) Seeing is believing: A fluorescent probe for monitoring the activity of dual-specific protein tyrosine phosphatases (PTPs) has been developed (see scheme). Selective enzymatic hydrolysis and subsequent intramolecular cyclization results in a highly fluorescent iminocoumarin fluorophore.

机译：（显示的图）眼见为实：已开发出一种用于监测双特异性蛋白酪氨酸磷酸酶（PTP）活性的荧光探针（请参见方案）。选择性酶水解和随后的分子内环化产生高度荧光的亚氨基香豆素荧光团。

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《Chemistry: A European journal》 |2010年第18期|共4页
作者
Kim T.-I.; Jeong M.S.; Chung S.J.; Kim Y.;
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正文语种 eng
中图分类应用化学;
关键词
Cyclization; Dual specificity; Fluorescent probes; Protein tyrosine phosphatases;

机译：环化;双重特异性;荧光探针;蛋白质酪氨酸磷酸酶;

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专利

1. An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases [J] . Kim T.-I., Jeong M.S., Chung S.J., Chemistry: A European journal . 2010,第18期

机译：基于亚氨基香豆素的荧光探针，可选择性检测双特异性蛋白酪氨酸磷酸酶
2. A selective Seoul-Fluor-based bioprobe, S/BP, for vaccinia Hl-related phosphatase—a dual-specific protein tyrosine phosphatase [J] . Myeong Seon Jeong, Eunha Kim, Hyo Jin Rang, Chemical Communications . 2012,第52期

机译：牛痘H1相关磷酸酶（一种双特异性蛋白酪氨酸磷酸酶）的选择性汉城基于生物探针S / BP
3. The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphatase. [J] . Denu JM, Zhou G, Guo Y, Biochemistry . 1995,第10期

机译：天门冬氨酸92在人类双特异性蛋白质酪氨酸磷酸酶中的催化作用。
4. Development of fluorescent molecular probe for imaging tyrosine phosphatase activity in cell nuclei [C] . Takashi Sakamoto 日本化学会春季年会講演予稿集 . 2018

机译：荧光分子探针的研制在细胞核中成像酪氨酸磷酸酶活性的荧光分子探针
5. Development, synthesis and applications of highly sensitive fluorescent probes for studying protein tyrosine phosphatases [D] . Mitra, Sayantan 2007

机译：用于研究蛋白质酪氨酸磷酸酶的高灵敏度荧光探针的开发，合成和应用
6. Development of a red fluorescent light-up probe for highly selective and sensitive detection of vicinal dithiol-containing proteins in living cells [O] . Yuanyuan Wang, Xiao-Feng Yang, Yaogang Zhong, 2016

机译：红色荧光发光探针的开发用于高度选择性和灵敏地检测活细胞中含邻二硫醇的蛋白质
7. Global Analysis of Protein Tyrosine Phosphatase Activity with Ultra-Sensitive Fluorescent Probes [O] . Sanjai Kumar, Bo Zhou, Fubo Liang, 2005

机译：用超敏感荧光探针进行蛋白酪氨酸磷酸酶活性的全局分析

An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases

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