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首页> 外文期刊>Urology >Long-term follow-up after laser therapy for penile carcinoma.
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Long-term follow-up after laser therapy for penile carcinoma.

机译：激光治疗阴茎癌后的长期随访。

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OBJECTIVES: Although in many cases of penile carcinoma, laser therapy has become the standard treatment, opinion still differs regarding the risks related to the relatively high rate of recurrence that accompanies this form of treatment. In this study, we reviewed the results of neodymium:yttrium-aluminum-garnet laser treatment of 44 consecutive patients with penile carcinoma in our institution from 1986 to 2003. METHODS: We created five groups, on the basis of the T stage and grade of the tumor. Of the 44 patients, 21 had Stage T1, 17 had Stage T2, and 6 had carcinoma in situ. RESULTS: Local disease recurrence (in the treated area) occurred in 48% of the treated patients, and in 20% of the patients, the first recurrence was elsewhere on the glans penis. These were subsequently treated by laser therapy or partial amputation. In 10 cases, nodal metastases were found. Eight of these cases were Stage T2. Our results suggest a stronger prognostic role for the primary T stage of the tumor than for the tumorgrade, with respect to the risk of nodal metastasis. CONCLUSIONS: From the high recurrence rate in our series, we decided to perform a wider initial laser excision and to diminish the number of retreatments to less than three. We also now believe that laser therapy is best for Stage Tis and T1 tumors exclusively. Only selected patients with T2 tumors should be treated in combination with early lymph node resection.
机译：目的：尽管在许多阴茎癌病例中，激光治疗已成为标准治疗方法，但是对于伴随这种治疗方法相对较高的复发率的风险仍存在不同意见。在这项研究中，我们回顾了1986年至2003年在该机构连续44例阴茎癌患者中使用钕：钇铝石榴石激光治疗的方法。方法：根据T分期和分期，我们分为5组。肿瘤。在这44例患者中，有21例为T1期，17例为T2期，6例为原位癌。结果：48％的治疗患者发生局部疾病复发（在治疗区域），而在20％的患者中，第一次复发发生在龟头的其他部位。随后对这些患者进行激光治疗或部分截肢。在10例中，发现了淋巴结转移。这些案例中有8个处于T2阶段。我们的结果表明，就淋巴结转移的风险而言，对于肿瘤的原发性T期而言，预后的作用要强于对肿瘤的预后。结论：由于我们系列中的高复发率，我们决定进行更广泛的初始激光切除，并将再次治疗的次数减少至少于3次。我们现在还认为，激光疗法仅对Tis和T1期肿瘤最好。只有部分T2肿瘤患者应与早期淋巴结切除术联合治疗。

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