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首页> 外文期刊>Urology >Smoking and risk of fatal prostate cancer in a prospective U.S. study.
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Smoking and risk of fatal prostate cancer in a prospective U.S. study.

机译：在一项前瞻性美国研究中，吸烟和致命的前列腺癌风险。

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OBJECTIVES: To examine the association of cigarette smoking with subsequent fatal prostate cancer. METHODS: Two private censuses were conducted in Washington County, Maryland, in which 26,810 adult men in 1963 and 28,292 in 1975 provided smoking information. Prostate cancer deaths through 2000 (1963 cohort, 240 deaths; and 1975 cohort, 184 deaths) were ascertained by review of the death certificates. Poisson regression analysis was used to estimate the rate ratio of prostate cancer death adjusted for age. RESULTS: Overall, cigarette smokers in the 1963 census cohort were not more likely to die of prostate cancer than those who had never smoked cigarettes, pipes, or cigars when considering the total follow-up period. However, current smokers of 20 or more cigarettes per day (rate ratio 2.38; 95% confidence interval 0.94 to 5.99) and former smokers (rate ratio 2.75; 95% confidence interval 1.13 to 6.74) had a greater risk of death from prostate cancer during the first 10 years of follow-up. Weaker positive associations of prostate cancer death with current and former cigarette smoking were seen during the first 10 years of follow-up in the 1975 census cohort. Current cigarette smoking at baseline was not associated with the prostate cancer incidence. CONCLUSIONS: The lack of an association between cigarette smoking and prostate cancer incidence, but the tendency of greater prostate cancer mortality in former and current cigarette smokers earlier in the follow-up period is consistent with other studies in which smoking was assessed once at baseline.
机译：目的：研究吸烟与随后致命的前列腺癌的关系。方法：在马里兰州华盛顿县进行了两次私人普查，1963年有26810名成年男子，1975年有28292名成年男子提供了吸烟信息。通过审查死亡证明，可以确定到2000年前列腺癌的死亡人数（1963年队列，240例死亡; 1975年队列，184例死亡）。使用泊松回归分析来估计根据年龄调整的前列腺癌死亡的比率。结果：总体而言，考虑到整个随访期，在1963年的人口普查队列中，吸烟者死于前列腺癌的几率比那些从未吸烟过香烟，烟斗或雪茄的人少。但是，目前每天吸烟20支或以上的吸烟者（比率为2.38; 95％置信区间为0.94至5.99）和以前吸烟者（比率为2.75; 95％置信区间为1.13至6.74）在此期间罹患前列腺癌的死亡风险更高。随访的前10年。在1975年的人口普查研究组随访的前10年中，发现前列腺癌死亡与现在和以前吸烟之间的弱正相关。当前在基线时吸烟与前列腺癌的发病率无关。结论：吸烟与前列腺癌的发病率之间没有关联，但是在随访期中，前吸烟者和当前吸烟者中前列腺癌死亡率更高的趋势与在基线评估吸烟一次的其他研究一致。

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