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首页> 外文期刊>Urology >Does benign prostatic tissue contribute to measurable PSA levels after radical prostatectomy?
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Does benign prostatic tissue contribute to measurable PSA levels after radical prostatectomy?

机译：前列腺癌根治术后良性前列腺组织是否有助于可测量的PSA水平？

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OBJECTIVES: To provide insights into the likelihood that benign prostatic tissue represents a source of measurable prostate-specific antigen (PSA) after radical prostatectomy. METHODS: From October 2000 to December 2006, 1308 consecutive men underwent open radical retropubic prostatectomy by a single surgeon. Of these 1308 men, 331 (25.3%) met our criteria for having "extremely" low-risk disease as determined by the preoperative and pathologic factors, including a preoperative PSA level <10 ng/mL, clinical Stage T1c or T2a, a Gleason score of < or =6, an estimated cancer volume in the specimen of <5%, and no evidence of positive surgical margins. This cohort was selected because any measurable PSA level would be highly suspicious for a benign origin. Undetectable PSA was defined as a PSA level of < or =0.04 ng/mL. A measurable PSA level included values between 0.05 and 0.14 ng/mL on > or =2 consecutive measurements 6 months apart. Biochemical recurrence was defined as 3 consecutively increasing PSA levels with a peak level of > or =0.15 ng/mL. RESULTS: At 3 months to 6 years of follow-up (mean 36.2 months), 0.6% and 0.3% of patients had developed a measurable PSA level or biochemical recurrence, respectively. The single patient with biochemical recurrence responded to salvage radiotherapy, strongly suggesting a malignant etiology for the recurrence. CONCLUSIONS: A measurable PSA level or biochemical recurrence was an extraordinarily rare event in our select group of patients with extremely low-risk disease. These results provide compelling evidence that retained benign prostatic elements are an unlikely source of elevated PSA levels in men who have undergone radical prostatectomy.
机译：目的：提供对前列腺癌根治术后良性前列腺组织代表可测量的前列腺特异性抗原（PSA）来源的可能性的见解。方法：从2000年10月至2006年12月，由单名外科医生进行的1308例连续男性行耻骨根治性前列腺切除术。在这1308名男性中，有331名（25.3％）符合我们的“极度”低危疾病标准，这是由术前和病理因素决定的，包括术前PSA水平<10 ng / mL，临床分期T1c或T2a，格里森评分<或= 6，标本中估计的癌症体积<5％，且无手术切缘阳性的证据。选择此队列的原因是，任何可衡量的PSA水平对于良性血统都是高度可疑的。未检测到的PSA被定义为PSA水平≤0.04 ng / mL。可测量的PSA水平包括相隔6个月的>或= 2连续测量值介于0.05和0.14 ng / mL之间的值。生化复发定义为PSA水平连续增加3次，峰值水平>或= 0.15 ng / mL。结果：在3个月至6年的随访中（平均36.2个月），分别有0.6％和0.3％的患者出现了可测量的PSA水平或生化复发。单个生化复发患者对挽救性放疗有反应，强烈提示复发的病因是恶性的。结论：在我们选择的极低风险疾病患者组中，可测量的PSA水平或生化复发是极为罕见的事件。这些结果提供了令人信服的证据，表明在接受前列腺癌根治术的男性中，残留的良性前列腺元素是PSA水平升高的不太可能的来源。

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