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首页> 外文期刊>Urology >Short-term histopathologic effects of different intracavernosal agents on corpus cavernosum and antifibrotic activity of intracavernosal verapamil: an experimental study.
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Short-term histopathologic effects of different intracavernosal agents on corpus cavernosum and antifibrotic activity of intracavernosal verapamil: an experimental study.

机译：不同海绵体内药物对海绵体和海绵体内维拉帕米的抗纤维化活性的短期组织病理学影响：一项实验研究。

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OBJECTIVES: To evaluate the short-term effects of different intracavernosal agents and to investigate the antifibrotic effect of verapamil combined with these intracavernosal agents. METHODS: Forty-five Sprague-Dawley rats weighing 400 to 500 g each (mean weight 435.27 +/- 13.65 g) were equally divided into nine groups (n = 5). Papaverine (group 1), alprostadil (group 2), sodium nitroprusside (group 3), and verapamil (group 4) were injected alone intracavernously in 0.2-mL doses. Verapamil combined with papaverine, alprostadil, and sodium nitroprusside in 0.2-mL doses (0.1 mL verapamil and 0.1 mL vasoactive agent) were injected in groups 5 through 7. Group 8 was kept as a control group without injection, and isotonic saline alone was injected in group 9 during the same period. The intracavernous injection was done twice weekly with a 4-day interval. At the end of the study, total penectomy and multiple liver biopsies were performed to evaluate the histopathologic effects of the vasoactive agents and to test the liver function. RESULTS: In all groups, the structure of the corpora cavernosa was well preserved generally and appeared similar to the control tissue. However, localized edema, fibrosis, macrophage infiltration, and polymorphonuclear leukocytes were found only at the injection site. Although these findings were not different from the findings in the saline and alprostadil groups, they were slightly more extensive in the papaverine and sodium nitroprusside alone groups and also in the vasoactive agent plus verapamil groups. Although mononuclear lymphocyte infiltration was found in the portal areas, advancing into the liver parenchyma, the liver function tests were within normal limits. CONCLUSIONS: We observed that intracavernous injection, except with nitroprusside, caused focal intracavernosal fibrosis and edema. We believe these effects might not be caused by just the drug, but also by needle trauma, since general fibrosis was not observed in the short term. However, nitroprusside has a severe fibrotic effect on cavernosal tissue in the short term. Moreover, intracavernous verapamil injection could not prevent the fibrosis in the short term.
机译：目的：评估不同的海绵体内药物的短期作用，并研究维拉帕米联合这些海绵体内药物的抗纤维化作用。方法：将四十五只体重为400至500 g（平均体重435.27 +/- 13.65 g）的Sprague-Dawley大鼠平均分为9组（n = 5）。罂粟碱（第1组），前列地尔（第2组），硝普钠（第3组）和维拉帕米（第4组）分别以0.2-mL剂量腔内注射。在第5到第7组中注射了0.2 mL剂量的维拉帕米联合罂粟碱，前列地尔和硝普钠（0.1 mL维拉帕米和0.1 mL血管活性剂），第8组作为对照组不注射，仅注射等渗盐水在同一时期的第9组中。海绵内注射每周两次，间隔4天。在研究结束时，进行了全切除术和多次肝活检，以评估血管活性剂的组织病理学作用并测试肝功能。结果：在所有组中，海绵体的结构总体上保存良好，并且看起来与对照组织相似。然而，仅在注射部位发现局部水肿，纤维化，巨噬细胞浸润和多形核白细胞。尽管这些发现与盐水和前列地尔组的发现没有什么不同，但在罂粟碱和硝普钠单独组以及血管活性剂加维拉帕米组中，它们的分布范围稍大。尽管在门静脉区域发现单核淋巴细胞浸润，并进入肝实质，但肝功能检查仍在正常范围内。结论：我们观察到，除硝普钠外，海绵体内注射均引起局灶性海绵体内纤维化和水肿。我们认为这些影响可能不仅是药物引起的，还可能是针头外伤引起的，因为短期内未观察到普遍的纤维化。然而，短期内硝普钠对海绵体组织具有严重的纤维化作用。此外，海绵状维拉帕米注射不能在短期内预防纤维化。

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