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首页> 外文期刊>Urology >Urokinase gene 3'-UTR T/C polymorphism is associated with urolithiasis.
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Urokinase gene 3'-UTR T/C polymorphism is associated with urolithiasis.

机译：尿激酶基因3'-UTR T / C多态性与尿石症有关。

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OBJECTIVES: To study single nucleotide polymorphisms to investigate the possibility that urokinase is involved in the formation of urolithiasis, which, although lacking in genetic evidence, has been previously proposed. METHODS: A total of 153 patients with recurrent calcium stones and 105 controls were studied. Polymerase chain reaction-based restriction analysis was used to identify the C/T polymorphism of the urokinase gene, which is mapped on the 3'-untranslated region (3'-UTR) on chromosome 10. RESULTS: A significant difference was found in the distribution of the urokinase gene 3'-UTR C/T polymorphism frequency between patients with stones and normal controls (P <0.05). The odds ratio for the risk of the T to 8.99). CONCLUSIONS: The results of our study demonstrate that the urokinase gene 3'-UTR "T" allele is associated with calcium stone disease. Individuals possessing the "T" allele have a higher incidence of calcium oxalate stone disease. The results of this study provide genetic evidence that the urokinase gene may play a role in stone formation.
机译：目的：研究单核苷酸多态性以研究尿激酶参与尿石症的形成的可能性，尿尿石症虽然缺乏遗传学证据，但先前已经提出。方法：对153例复发性钙结石患者和105例对照进行了研究。基于聚合酶链反应的限制性酶切分析用于鉴定尿激酶基因的C / T多态性，该基因定位在10号染色体的3'-非翻译区（3'-UTR）上。结果：结石患者与正常人之间尿激酶基因3'-UTR C / T多态性频率的分布（P <0.05）。 T风险的比值比为8.99）。结论：我们的研究结果表明，尿激酶基因3'-UTR“ T”等位基因与钙结石病有关。具有“ T”等位基因的个体发生草酸钙结石疾病的几率更高。这项研究的结果提供了遗传证据，证明尿激酶基因可能在结石形成中起作用。

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