Activating Water: Efficient Intramolecular General Base Catalysis of the Hydrolysis of a Phosphate Triester

Anthony J. Kirby; Michelle Medeiros; Pedro S. M. Oliveira; Tiago A. S. Brandao; Faruk Nome

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Activating Water: Efficient Intramolecular General Base Catalysis of the Hydrolysis of a Phosphate Triester

机译：活化水：磷酸三酯水解的高效分子内通用碱催化

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We have identified the first highly efficient intramolecular general base catalysis (IGBC) of a hydrolysis reaction, in a system where two general bases are available to assist the attack of the same nucleophilic water molecule. The suggested mechanism, available uniquely to a phosphate triester model, is readily available in enzyme active sites, and the results suggest a possible solution to the longunsolved question of how enzymes are able to activate a water molecule to be a highly effective nucleophile.

机译：我们已经确定了水解反应的第一个高效分子内通用碱催化（IGBC），该系统中有两个通用碱可用于协助相同亲核水分子的攻击。所提出的机制是磷酸三酯模型唯一可用的机制，可在酶活性位点容易获得，结果提示了一个长期未解决的问题的可能解决方案，该问题是酶如何能够激活水分子成为高效亲核试剂。

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《Chemistry: A European journal》 |2009年第34期|共5页
作者
Anthony J. Kirby; Michelle Medeiros; Pedro S. M. Oliveira; Tiago A. S. Brandao; Faruk Nome;
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正文语种 eng
中图分类 540E0070;
关键词
bioorganic chemistry; enzyme catalysis; hydrolysis; intramolecular catalysis; phosphate transfer;

机译：生物有机化学;酶催化;水解;分子内催化;磷酸盐转移;

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1. Activating Water: Efficient Intramolecular General Base Catalysis of the Hydrolysis of a Phosphate Triester [J] . Anthony J. Kirby, Michelle Medeiros, Pedro S. M. Oliveira, Chemistry: A European journal . 2009,第34期

机译：活化水：磷酸三酯水解的高效分子内通用碱催化
2. Activating Water: Important Effects of Non-leaving Groups on the Hydrolysis of Phosphate Triesters [J] . Prof. Anthony J. Kirby, Michelle Medeiros, Pedro S. M. Oliveira, Chemistry - A European Journal . 2011,第52期

机译：活化水：非离去基团对磷酸三酯水解的重要影响
3. Activating water: Important effects of non-leaving groups on the hydrolysis of phosphate triesters [J] . Kirby A.J., Medeiros M., Oliveira P.S.M., Chemistry: A European journal . 2011,第52期

机译：活化水：非离去基团对磷酸三酯水解的重要作用
4. (00908)Bio-Based Phosphate Functionalized Activated Carbon from Indian Gooseberry Seed Shells for the Efficient Copper (II)Adsorption [C] . Mondal S., Majumder S.K. International Conference on Environmental Science and Technology . 2019

机译：（00908）来自印度醋酸种子壳的生物基磷酸盐官能化活性炭，用于高效铜（II）吸附
5. METALLOENZYME MODELS. PART I: NITROGEN ANALOGUES OF CYTOCHROME P-450 MODEL REACTIONS. PART II: ZINC-BASED CATALYSTS FOR PHOSPHATE TRIESTER HYDROLYSIS [D] . GELLMAN, SAMUEL HELMER 1986

机译：金属酶模型。第一部分：细胞色素P-450模型反应的氮类似物。第二部分：磷酸盐三酯水解的锌基催化剂
6. Efficient Hydrogen Generation From Hydrolysis of Sodium Borohydride in Seawater Catalyzed by Polyoxometalate Supported on Activated Carbon [O] . Senliang Xi, Xiaojun Wang, Dan Wu, 2020

机译：活性炭负载氢相催化的海水中硼氢化钠水解的高效产生
7. Solvolysis of Organic Phosphates. VI. Intramolecular Catalysis in the Hydrolysis of 2-Pyridylalkyl Phosphates [O] . Yukito Murakami, Junzo Sunamoto, Naomi Kanamoto 1973

机译：有机磷酸盐的溶剂解。 VI。分子内催化在水解2-吡啶烷基烷基酯的水解中
8. Intramolecular Catalysis of Dialkyl Omega-Aminoalkylphosphonate Hydrolysis [R] . Leslie, D. R., Pantelidis, S. 1994

机译：二烷基ω-氨基烷基膦酸酯水解的分子内催化

Activating Water: Efficient Intramolecular General Base Catalysis of the Hydrolysis of a Phosphate Triester

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