Characterisation of the MMP-12–Elastin Adduct

Ivano Bertini; Marco Fragai; Claudio Luchinat; Maxime Melikian; Chiara Venturi

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Characterisation of the MMP-12–Elastin Adduct

机译：MMP-12-弹性蛋白加合物的表征

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MMP-12 (matrix metalloproteinase 12)is an important protein of the MMP family.~[1–4] Its substrate is elastin,~[5–8] which is composed of a cross-linked insoluble network of polypeptide chains of tropoelastin of MW 65 kDa each.~[9] Insoluble elastin is responsible for keeping some extracellular connective tissues elastic.

机译：MMP-12（基质金属蛋白酶12）是MMP家族的重要蛋白质。〜[1-4]的底物是弹性蛋白，〜[5-8]，由交联的不溶原弹性蛋白多肽链组成。每个MW 65 kDa。〜[9]不溶弹性蛋白负责保持某些细胞外结缔组织的弹性。

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《Chemistry: A European journal》 |2009年第32期|共4页
作者
Ivano Bertini; Marco Fragai; Claudio Luchinat; Maxime Melikian; Chiara Venturi;
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正文语种 eng
中图分类应用化学;
关键词
enzyme catalysis; metalloenzymes; NMRspectroscopy; peptides; reaction mechanisms;

机译：酶催化;金属酶;NMR光谱;多肽;反应机理;

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专利

1. Characterisation of the MMP-12–Elastin Adduct [J] . Ivano Bertini, Marco Fragai, Claudio Luchinat, Chemistry: A European journal . 2009,第32期

机译：MMP-12-弹性蛋白加合物的表征
2. N-O-Isopropyl sulfonamido-based hydroxamates: Kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors [J] . SantamariaS., NutiE., CercignaniG., Biochemical Pharmacology . 2012,第6期

机译：N-O-异丙基磺酰胺基异羟肟酸酯：一系列MMP-12 / MMP-13双靶标抑制剂的动力学表征
3. Supramolecular interactions in itaconic acid-2-amino-4,6-dimethylpyrimidine molecular adduct: Physicochemical characterisation and quantum chemical calculations for the molecular adduct [J] . Muthuraja P., Aparna V. S., Beaula T. Joselin, The journal of physics and chemistry of solids . 2019,第期

机译：衣康酸-2-氨基-4,6-二甲基嘧啶分子加合物的超分子相互作用：物理化学表征和分子加合的量子化学计算
4. Development and Characterisation of a Novel Elastin Hydrogel [C] . Nasim Annabi, Suzanne M. Mithieux, Anthony S. Weiss, Symposium HH on Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging . 2009

机译：新型ELASTIN水凝胶的开发和表征
5. Adduct conformational polymorphism explains adduct mutational complexity based on studies of the major adduct of benzo(a)pyrene in a mutational hotspot. [D] . Jelinsky, Scott A. 1997

机译：加合物构象多态性基于突变热点中苯并（a）py的主要加合物的研究，解释了加合物突变的复杂性。
6. Obesity-induced remodeling of the adipose tissue elastin network is independent of the metalloelastase MMP-12 [O] . Gabriel Martinez-Santibanez, Kanakadurga Singer, Kae Won Cho, 2015

机译：肥胖引起的脂肪组织弹性蛋白网络重塑独立于金属弹性蛋白酶MMP-12
7. Characterisation of hydration and nanophase separation during the temperature response in hydrophobic/ hydrophilic elastin-like polypeptide (ELP) diblock copolymers [O] . Widder, Katharina, MacEwan, Sarah R., Garanger, Elisabeth, 2017

机译：疏水/亲水弹性蛋白样多肽（ELP）二嵌段共聚物在温度响应过程中的水合作用和纳米相分离的表征
8. Studies of Elastin as a Biomaterial:The Correlation of Surface Composition with Effects on Platelets and Clotting by Native,Altered,and Reconstituted Elastin. [R] . brown,john f. jr bergeron,john a. 1976

机译：弹性蛋白作为生物材料的研究：表面组成与天然，改变和重组弹性蛋白对血小板和凝固的影响的相关性。

Characterisation of the MMP-12–Elastin Adduct

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