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首页> 外文期刊>Urology >Prostate-specific antigen in men born with bladder exstrophy.
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Prostate-specific antigen in men born with bladder exstrophy.

机译：患有膀胱萎缩症的男性前列腺特异性抗原。

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OBJECTIVES: To determine serum levels of prostate-specific antigen (PSA) in men born with bladder exstrophy and to investigate the clinical utility of this test in the bladder exstrophy population. METHODS: Ten men aged 19 to 45 years with a history of bladder exstrophy underwent digital rectal examination and free and total serum PSA determinations. Immunohistochemistry for PSA and prostate-specific acid phosphatase (PSAP) was performed on archival prostate tissue from 1 man with bladder exstrophy. RESULTS: Free and total serum PSA levels for all patients were measurable and below the upper limit for established age-specific reference ranges for normal men. Both PSA and PSAP were detectable by immunohistochemistry in prostate epithelial cells of a man with bladder exstrophy. CONCLUSIONS: Men born with bladder exstrophy have detectable serum PSA levels. However, because prostate cancer in men with bladder exstrophy has not been reported, whether PSA will have a clinical role as a serum tumor marker forprostate cancer in this population remains to be determined. If so, the PSA reference range for men with the exstrophy condition will need to be defined. Because prostate histology in men with exstrophy resembles that of normal men, careful clinical monitoring for benign and malignant tumors should not be overlooked in this particular population.
机译：目的：确定患有膀胱营养不良的男性的血清前列腺特异性抗原（PSA）的水平，并研究该测试在膀胱营养不良人群中的临床应用。方法：十名年龄在19至45岁之间，有膀胱外翻史的男性接受了直肠指检，并进行了游离和总血清PSA测定。 PSA和前列腺特异性酸性磷酸酶（PSAP）的免疫组织化学是在1名患有膀胱萎缩症的人的档案前列腺组织上进行的。结果：所有患者的游离和总血清PSA水平均可测量，且低于正常男性确定的特定年龄参考范围的上限。 PSA和PSAP均可通过免疫组织化学在患有膀胱萎缩症的男性的前列腺上皮细胞中检测到。结论：患有膀胱外翻的男性具有可检出的血清PSA水平。然而，由于尚未报道患有膀胱萎缩症的男性的前列腺癌，因此尚需确定PSA作为该人群前列腺癌的血清肿瘤标志物是否具有临床作用。如果是这样，则需要确定患有外翻性疾病的男性的PSA参考范围。由于异位男性的前列腺组织学与正常男性相似，因此在这一特殊人群中，对良性和恶性肿瘤的仔细临床监测不容忽视。

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