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首页> 外文期刊>Urology >Novel dual-lumen ureteral stents provide better ureteral flow than single ureteral stent in ex vivo porcine kidney model of extrinsic ureteral obstruction.
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Novel dual-lumen ureteral stents provide better ureteral flow than single ureteral stent in ex vivo porcine kidney model of extrinsic ureteral obstruction.

机译：在体外输尿管阻塞的猪肾脏模型中，新型双腔输尿管支架比单支输尿管支架提供更好的输尿管流量。

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摘要

OBJECTIVES: In the instance of extrinsic ureteral obstruction, indwelling ureteral stents have a high failure rate. Although technically challenging, simultaneous insertion of two ipsilateral stents can achieve better flow rates with time. A novel dual-lumen stent, composed of two adhered ureteral stents, offers the additional benefit of easier placement than a single guidewire. Using a novel ex vivo porcine model, the flow rates within an extrinsically obstructed renal unit were evaluated using two internal ipsilateral stents and two prototype double-lumen stents. METHODS: Sixteen renal units were harvested from eight adult Yorkshire female pigs. To quantify flow, the kidneys were infused at a constant pressure, and the corresponding ureteral drainage was measured for a defined interval. The flow was measured with a standard 7F double-pigtail stent, two ipsilateral 7F double-pigtail stents, a 7F novel double-lumen stent designed with both distal lumens open, and a 7F novel double-lumen stent with one distal lumen closed. The intraluminal and extraluminal flow in obstructed and nonobstructed systems was measured. RESULTS: The two ipsilateral standard stents or prototype double stents achieved better flow down the ureter than did one standard stent (P <0.05). The intraluminal and extraluminal flow in the novel stents was statistically greater than the corresponding flow in the standard double-pigtail stent (P <0.01). The extraluminal and obstructed flow was lowest for the standard double-pigtail stent. CONCLUSIONS: Novel dual-lumen prototype ureteral stents provided better flow than a single stent in extrinsically obstructed ureters with the proposed added benefit of easier retrograde insertion compared with a single guidewire.
机译：目的：在输尿管外在阻塞的情况下，留置输尿管支架的失败率很高。尽管在技术上具有挑战性，但同时插入两个同侧支架可以随时间获得更好的流速。由两个粘附的输尿管支架组成的新型双腔支架，比单根导丝更易于放置。使用新型离体猪模型，使用两个内部同侧支架和两个原型双腔支架评估外部阻塞的肾脏单位内的流速。方法：从八只成年约克夏雌猪中收获十六个肾脏单位。为了量化流量，在恒定压力下输注肾脏，并在确定的时间间隔内测量相应的输尿管引流。使用标准的7F双尾纤支架，两个同侧7F双尾纤支架，设计为两个远端腔均打开的7F新型双腔支架以及闭合一个远端腔的7F新型双腔支架来测量流量。测量了阻塞和非阻塞系统的腔内和腔外流量。结果：两个同侧标准支架或原型双支架比一个标准支架的输尿管顺流性更好（P <0.05）。统计上，新型支架的腔内和腔外流量大于标准双尾纤支架的相应流量（P <0.01）。对于标准双尾纤支架，管腔外和阻塞血流最低。结论：新型双腔输尿管原型支架在外在阻塞的输尿管中比单支架提供更好的血流，与单根导丝相比，其建议的优点是更容易逆行插入。

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