Allosteric molecular beacons for sensitive detection of nucleic acids, proteins, and small molecules in complex biological samples

Song Y.; Cui L.; Wu J.; Zhang W.; Zhang W.Y.; Kang H.; Yang C.J.

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Allosteric molecular beacons for sensitive detection of nucleic acids, proteins, and small molecules in complex biological samples

机译：变构分子信标，用于灵敏检测复杂生物样品中的核酸，蛋白质和小分子

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Beacon of light! A new type of probe called an allosteric molecular beacon (aMB) has been designed for highly sensitive detection of nucleic acids, proteins, and small molecules. The aMB is designed in such way that target binding will activate its binding affinity to streptavidin microbeads for probe signal enrichment, noise reduction, and signal readout, which enables ultrasensitive target detection in complex biological samples (see scheme).

机译：灯塔的光！设计了一种新型的名为变构分子信标（aMB）的探针，用于高度敏感地检测核酸，蛋白质和小分子。 aMB的设计使靶标结合将激活其与链霉亲和素微珠的结合亲和力，以进行探针信号富集，降噪和信号读出，从而能够在复杂的生物样品中进行超灵敏的靶标检测（请参阅方案）。

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《Chemistry: A European journal》 |2011年第33期|共5页
作者
Song Y.; Cui L.; Wu J.; Zhang W.; Zhang W.Y.; Kang H.; Yang C.J.;
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原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
allosteric probes; aptamers; DNA; fluorescent probes; molecular beacons; proteins;

机译：变构探针;适体;DNA;荧光探针;分子信标;蛋白质;

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1. Allosteric molecular beacons for sensitive detection of nucleic acids, proteins, and small molecules in complex biological samples [J] . Song Y., Cui L., Wu J., Chemistry: A European journal . 2011,第33期

机译：变构分子信标，用于灵敏检测复杂生物样品中的核酸，蛋白质和小分子
2. Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins, and Small Molecules in Complex Biological Samples [J] . Yanling Song, Liang Cui, Jie Wu, Chemistry - A European Journal . 2011,第33期

机译：用于复杂生物样品中核酸，蛋白质和小分子灵敏检测的变构分子信标
3. Inside Cover: Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins, and Small Molecules in Complex Biological Samples (Chem. Eur. J. 33/2011) [J] . Yanling Song, Liang Cui, Jie Wu, Chemistry - A European Journal . 2011,第33期

机译：封面内容：变构分子信标，用于敏感地检测复杂生物样品中的核酸，蛋白质和小分子（Chem。Eur。J. 33/2011）
4. Single-Molecule Electronic Detection of Nucleic Acids and Proteins: A New Paradigm for Genetic Analyses and Biomedical Applications [C] . Chuanjuan Tao, Shiv Kumar, Minchen Chien, International Conference on Biomedical Engineering and Sciences . 2018

机译：单分子电子检测核酸和蛋白质：遗传分析和生物医学应用的新范式
5. Development and optimization of dual FRET-molecular beacons for the detection and visualization of single-stranded nucleic acid targets. [D] . Tsourkas, Andrew. 2002

机译：开发和优化用于检测和可视化单链核酸靶标的双FRET分子信标。
6. Development of a Quantitative Real-Time Nucleic Acid Sequence-Based Amplification Assay with an Internal Control Using Molecular Beacon Probes for Selective and Sensitive Detection of Human Rhinovirus Serotypes [O] . Francesca Sidoti, Massimiliano Bergallo, Maria Elena Terlizzi, -1

机译：使用分子信标探针对人类鼻病毒血清型进行选择性和灵敏检测的内部对照定量实时核酸序列扩增试验的开发。
7. Inside Cover: Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins, and Small Molecules in Complex Biological Samples (Chem. Eur. J. 33/2011) [O] . Yanling Song, Liang Cui, Jie Wu, 2011

机译：内部盖子：复杂生物样品中核酸，蛋白质和小分子敏感检测的变构分子信标（Chem.Eur。J.33/2011）
8. NanoCluster Beacon - A New Molecular Probe for Homogeneous Detection of Nucleic Acid Targets. [R] . Yeh, H., Sharma, J., Han, J. J., 2011

机译：NanoCluster Beacon - 核酸靶均相检测的新分子探针。

Allosteric molecular beacons for sensitive detection of nucleic acids, proteins, and small molecules in complex biological samples

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