Highly efficient Rh~I-catalyzed asymmetric hydrogenation of β-amino acrylonitriles

Ma M.; Hou G.; Sun T.; Zhang X.; Li W.; Wang J.; Zhang X.

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Highly efficient Rh~I-catalyzed asymmetric hydrogenation of β-amino acrylonitriles

机译：Rh〜I高效催化β-氨基丙烯腈的不对称加氢

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(Figure Presented) It takes two to TangPhos: β-Amino acrylonitriles can be readily prepared from acetonitriles. Both of the E/Z isomers undergo hydrogenation with excellent enantioselectivity by using the Rh-TangPhos (TangPhos = l, 1'-ditert-butyl-(2, 2')-diphospholane) catalyst system. The products, chiral β-amino nitriles, are valuable chiral building blocks for many drugs.

机译：（显示的图）TangPhos需要两个步骤：β-氨基丙烯腈可以很容易地由乙腈制备。通过使用Rh-TangPhos（TangPhos = 1，1'-二叔丁基-（2，2'）-二膦环烷）催化剂体系，两种E / Z异构体均以优异的对映选择性进行氢化。手性β-氨基腈是许多药物的重要手性基石。

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《Chemistry: A European journal》 |2010年第18期|共4页
作者
Ma M.; Hou G.; Sun T.; Zhang X.; Li W.; Wang J.; Zhang X.;
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原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
Acrylonitriles; Enantioselectivity hydrogenation; P ligands; Rhodium;

机译：丙烯腈;对映选择性加氢;P配体;铑;

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专利

1. Highly efficient Rh~I-catalyzed asymmetric hydrogenation of β-amino acrylonitriles [J] . Ma M., Hou G., Sun T., Chemistry: A European journal . 2010,第18期

机译：Rh〜I高效催化β-氨基丙烯腈的不对称加氢
2. Highly efficient asymmetric hydrogenation of cyano-substituted acrylate esters for synthesis of chiral γ-lactams and amino acids [J] . Duanyang Kong, Meina Li, Rui Wang, Organic & biomolecular chemistry . 2016,第4期

机译：氰基取代的丙烯酸酯的高效不对称氢化，用于合成手性γ-内酰胺和氨基酸
3. Highly Efficient Synthesis of Heterocyclic and Alicyclic β~2-Amino Acid Derivatives by Catalytic Asymmetric Hydrogenation [J] . Lanning Li, Bin Chen, Yuanyuan Ke, Chemistry, an Asian journal . 2013,第9期

机译：催化不对称加氢高效合成杂环和脂环族β〜2-氨基酸衍生物
4. Asymmetric Hydrogenation of an Amino Acid Intermediate in the Synthesis of Complex Drug Targets: From Kinetic Modeling to Process Development [C] . Daniel S. Hsieh, Dong Lin, Steve S.Y. Wang, Conference on the Catalysis of Organic Reactions . 2009

机译：复合药物靶标中氨基酸中间体的不对称氢化：从动力学建模到过程开发
5. Highly efficient asymmetric synthesis of novel diphosphine ligands with additional chiral centers on the backbone and their applications in asymmetric hydrogenation reactions. [D] . Qiu, Liqin. 2003

机译：在骨架上具有额外手性中心的新型二膦配体的高效不对称合成及其在不对称氢化反应中的应用。
6. Highly efficient Ir-catalyzed asymmetric hydrogenation of benzoxazinones and derivatives with a Brønsted acid cocatalyst [O] . Zhengyu Han, Gang Liu, Rui Wang, 2011

机译：布朗斯台德酸助催化剂的高效Ir催化苯并恶嗪酮及其衍生物的不对称加氢反应
7. Highly Enantioselective Asymmetric Hydrogenation of alpha-Phthalimide Ketone: An Efficient Entry to Enantiomerically Pure Amino Alcohols [O] . -1

机译：α-邻苯二甲醚酮高度对映选择性的不对称氢化：高效进入对映体纯氨基醇

Highly efficient Rh~I-catalyzed asymmetric hydrogenation of β-amino acrylonitriles

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