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Immunosuppressive resveratrol aneuploids from Hopea chinensis

机译:中华白桦的免疫抑制性白藜芦醇非整倍体

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摘要

Two novel resveratrol aneuploids, hopeachinols A (1) and B (2), as well as a potent immunosuppressive polyphenol diptoindonesin G (3) were characterized from the ethanol extract of Hopea chinensis stem barks. The structure of the polyphenols was accommodated by comprehensive spectroscopic analysis with the absolute stereochemistry determined by the CD approach coupled with theoretical ECD spectra computer-generated through the Gaussian 03 program. The distinct structure and biological profile of 3 recommended it as a starting molecule for the relevant drug discovery.
机译:两种新型白藜芦醇非整倍体,希望蛋白A(1)和B(2),以及有效的免疫抑制性多酚二吲哚酮G(3),均是从Hopea chinensis茎皮的乙醇提取物中鉴定出来的。多酚的结构通过全面的光谱分析进行调整,其绝对立体化学由CD方法确定,再加上通过高斯03程序计算机生成的理论ECD光谱。 3的独特结构和生物学特性推荐它作为相关药物发现的起始分子。

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