Asymmetric organocatalytic formal aza-Michael addition of ammonia to nitroalkenes

Lykke L.; Monge D.; Nielsen M.; J?rgensen K.A.

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Asymmetric organocatalytic formal aza-Michael addition of ammonia to nitroalkenes

机译：氨向硝基烯烃的不对称有机催化形式氮杂-迈克尔加成反应

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The formal addition of ammonia to nitroalkenes, affording optically active β-amino nitro compounds in high yields and enantioselectivities, is presented (see scheme). The approach is based on a novel thiourea-catalyzed aza-Michael reaction, by which benzophenone imine serves as a masked ammonia equivalent, which is released by hydrolysis.

机译：提出了将氨正式加入硝基烯烃中，从而以高收率和对映选择性提供旋光性β-氨基硝基化合物的方法（请参见方案）。该方法基于一种新型的硫脲催化的aza-Michael反应，通过该反应，二苯甲酮亚胺用作掩蔽的氨当量，其通过水解释放。

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《Chemistry: A European journal》 |2010年第45期|共5页
作者
Lykke L.; Monge D.; Nielsen M.; J?rgensen K.A.;
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正文语种 eng
中图分类应用化学;
关键词
alkenes; Michael addition; nitroalkenes; organocatalysis;

机译：烯烃;迈克尔加成;硝基烯烃;有机催化;

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1. Asymmetric organocatalytic formal aza-Michael addition of ammonia to nitroalkenes [J] . Lykke L., Monge D., Nielsen M., Chemistry: A European journal . 2010,第45期

机译：氨向硝基烯烃的不对称有机催化形式氮杂-迈克尔加成反应
2. Organocatalytic enantioselective formal synthesis of bromopyrrole alkaloids via aza-Michael addition [J] . Su-Jeong Lee, Seok-Ho Youn, Chang-Woo Cho Organic & biomolecular chemistry . 2011,第22期

机译：氮杂-迈克尔加成反应对溴吡咯生物碱的有机催化对映体选择性合成
3. Asymmetric aza-Michael additions of 4-nitrophthalimide to nitroalkenes and preliminary study of the products for herbicidal activities [J] . Ma S., Wu L., Liu M., Tetrahedron . 2013,第12期

机译：4-硝基邻苯二甲酰亚胺在硝基烯烃中的不对称氮杂-迈克尔加成反应及其除草活性的初步研究
4. Tropos Benzophenone-like Phosphoramidite Ligands: Highly Enantioselective Catalyses of Conjugate Addition to Nitroalkenes irrespective of the Reagents and Substrates [C] . Kazuki Wakabayashi, Kohsuke Aikawa, Koichi Mikami Symposium on Organometallic Chemistry . 2007

机译：Tropos二苯酮样磷酰亚胺配体：无论试剂和衬底如何，硝基烯烃的缀合物的高度映射性催化剂
5. Part I. Asymmetric organocatalysis: (1) Direct enantioselective organocatalytic hydroxymethylation of aldehydes catalyzed by alpha,alpha-diphenylprolinol trimethylsilyl ether: Application in the formal synthesis of (-)-Rasfonin; (2) Synthesis of a novel bicyclic secondary amine organocatalyst: Application to the direct enantioselective organocatalytic hydroxymethylation of aldehydes. Part II. Asymmetric synthesis of bicyclic analogues of the anti-osteoporotic drug risedronate. [D] . Miller, John Robert. 2010

机译：第一部分，不对称有机催化：（1）α，α-二苯基脯氨醇三甲基甲硅烷基醚催化的醛的直接对映选择性有机催化羟甲基化：在（-）-Rasfonin的正式合成中的应用；（2）新型双环仲胺有机催化剂的合成：应用于醛的直接对映选择性有机催化羟甲基化。第二部分抗骨质疏松药物Risedronate的双环类似物的不对称合成。
6. Organocatalytic Asymmetric Conjugate Addition of Aldehydes to Maleimides and Nitroalkenes in Deep Eutectic Solvents [O] . Alejandro Torregrosa-Chinillach, Alba Sánchez-Laó, Elisa Santagostino, 2019

机译：深共晶溶剂中醛向顺丁烯二酰亚胺和硝基烯烃的有机催化不对称共轭加成反应
7. Organocatalytic Asymmetric Conjugate Addition of Aldehydes to Maleimides and Nitroalkenes in Deep Eutectic Solvents [O] . Alejandro Torregrosa-Chinillach, Alba Sánchez-Laó, Elisa Santagostino, 2019

机译：有机催化不对称缀合物加入到Malimidides和Nitectectic溶剂中的马来酰亚胺和硝基烯烃

Asymmetric organocatalytic formal aza-Michael addition of ammonia to nitroalkenes

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