Efficient and stereoselective synthesis of bicyclo[3.2.1]octan-8-ones:synthesis and palladium-catalyzed isomerization of functionalized 2-vinyl-2,3,3a,4,5,6-hexahydro-2,3-benzofurans

Peter Langer; Edith Holtz; Nehad N.R.Saleh

首页> 外文期刊>Chemistry: A European journal >Efficient and stereoselective synthesis of bicyclo[3.2.1]octan-8-ones:synthesis and palladium-catalyzed isomerization of functionalized 2-vinyl-2,3,3a,4,5,6-hexahydro-2,3-benzofurans

【24h】

Efficient and stereoselective synthesis of bicyclo[3.2.1]octan-8-ones:synthesis and palladium-catalyzed isomerization of functionalized 2-vinyl-2,3,3a,4,5,6-hexahydro-2,3-benzofurans

机译：高效和立体选择性合成双环[3.2.1] octan-8-ones：官能化的2-乙烯基-2,3,3a，4,5,6-六氢-2,3-苯并呋喃的合成和钯催化的异构化

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A new C,O-cyclodialkylation of dilithiated cycli #beta#-ketoesters and #beta#-keto sulfones with 1,4-dibromo-2-butene is reported which results in regio- and diastereoselective formation of 2-vinyl-2,3,3a,4,5,6-hexahydro-2,3-benzofurans.The products could beefficiently transformed into functionalized bicycol[3.2]octan-8-ones by a palladium-catalyzed with high stereospecifity to give exclusively the endoconfigured diastereomers.The bicyclo[3.2.1]octane skeleton is present in a large number of pharmacologically important natural products.

机译：据报道，新的C，O-环二烷基化的双锂化的β-β-酮酸酯和＃β＃-酮砜与1,4-二溴-2-丁烯的反应，导致2-乙烯基-2,3的区域和非对映选择性形成，3a，4,5,6-hexahydro-2,3-苯并呋喃。该产物可通过钯以高立体专一性有效地转化为功能化的Bicycol [3.2] octan-8-ones，从而仅得到内构非对映异构体。 [3.2.1]辛烷骨架存在于许多重要的药理天然产物中。

著录项

来源
《Chemistry: A European journal》 |2002年第4期|共12页
作者
Peter Langer; Edith Holtz; Nehad N.R.Saleh;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;应用化学;
关键词
dianions; cyclization; diastereoselectivity; palladium; regioselectivity;

机译：二价阴离子;环化;非对映选择性;钯;区域选择性;

相似文献

外文文献
中文文献
专利

1. Efficient and stereoselective synthesis of bicyclo[3.2.1]octan-8-ones:synthesis and palladium-catalyzed isomerization of functionalized 2-vinyl-2,3,3a,4,5,6-hexahydro-2,3-benzofurans [J] . Peter Langer, Edith Holtz, Nehad N.R.Saleh Chemistry: A European journal . 2002,第4期

机译：高效和立体选择性合成双环[3.2.1] octan-8-ones：官能化的2-乙烯基-2,3,3a，4,5,6-六氢-2,3-苯并呋喃的合成和钯催化的异构化
2. STEREOSELECTIVE SYNTHESIS OF 2-EXO-FUNCTIONALIZED BICYCLO[3.2.1]OCT-3-EN-8-ONES BY IRON MEDIATED CARBONYLATION OF BICYCLO[4.1.0]HEPT-2-ENES [J] . Tewes G., Eilbracht P., Hirschfelder A. Tetrahedron . 1996,第15期

机译：铁介导的双环[4.1.0]庚基-2-烯的羰基化立体合成2-EXO官能化的双环[3.2.1] OCT-3-EN-8-ones
3. Synthesis of functionalized 2-vinyl-2,3- di hydro pyrroles and 3-methylene-1,2,3,4-tetrahydropyridines by palladium-catalyzed cyclization of β-enaminocarbonyl compounds with allylic bisacetates [J] . Masahiro Yoshida, Kouki Kinoshita, Kosuke Namba Organic & biomolecular chemistry . 2014,第15期

机译：钯催化烯丙基双乙酸酯催化β-烯氨基羰基化合物环化反应合成官能化的2-乙烯基-2,3-二氢吡咯和3-亚甲基-1,2,3,4-四氢吡啶
4. Synthesis, Structure and Isomerization of the Heavy Bicyclo1.1.0butane Derivatives Composed of the Group 14-16 Elements [C] . Shogo Miyazaki, Vladimir Ya. Lee, Akira Sekiguchi Symposium on Organometallic Chemistry . 2007

机译：重型的合成，结构和异构化1.1.0由第14-16组元素组成的丁烷衍生物
5. Part I: Total Synthesis of (+/-)-Pallambins C and D, and, Part II: Gold-Catalyzed Tandem Cyclization towards Substituted Bicyclo[3.2.1]Octenone Derivatives: Lead to Total Synthesis of Dhilirolides A-D. [D] . Xu, Xuesong. 2013

机译：第一部分：（+/-）-戊二烯C和D的全合成，第二部分：金催化的串联环化反应取代双环[3.2.1]大黄酮衍生物：导致Dhilirolides A-D的全合成。
6. Synthesis of Highly Functionalised Enantiopure Bicyclo3.2.1- octane Systems from Carvone [O] . Antonio Abad, Consuelo Agulló, Ana C. Cuñat, 2004

机译：由香芹酮合成高功能对映纯双环3.2.1-辛烷体系
7. 3-Trimethylsilylbicyclo3.2.1oct-2-ene in the synthesis of functionalized bicyclo3.2.1octane systems [O] . Govindagouda Pati S., Nagendrappa G. 2002

机译：3-三甲基甲硅烷基双环3.2.1辛-2-烯在官能化双环3.2.1辛烷体系的合成中的应用

Efficient and stereoselective synthesis of bicyclo[3.2.1]octan-8-ones:synthesis and palladium-catalyzed isomerization of functionalized 2-vinyl-2,3,3a,4,5,6-hexahydro-2,3-benzofurans

摘要

著录项

相似文献

相关主题

期刊订阅