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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Fibrin glue is useful in preventing early dialysate leakage in children on chronic peritoneal dialysis.
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Fibrin glue is useful in preventing early dialysate leakage in children on chronic peritoneal dialysis.

机译：纤维蛋白胶可用于预防慢性腹膜透析患儿的早期透析液渗漏。

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摘要

OBJECTIVE: To assess if application of fibrin glue sealant to the peritoneal cuff suture is useful in the prevention of early dialysate leakage in children with end-stage renal disease on chronic peritoneal dialysis (CPD). DESIGN: Single-center, open-label, prospective randomized study. SETTING: University Pediatric Hospital. METHODS: 52 catheters were implanted in 45 children (mean age 6.2 +/- 4.5 years). Catheters were randomly assigned to either the control group or the sealant group. In the latter group, 1 mL of fibrin glue sealant was applied to the peritoneal cuff suture. 18 catheters were used for the first time within 5 days after implantation (early-used catheters). Leakage, exit-site or tunnel infection, peritonitis, and adverse secondary effects were evaluated during the initial 60 days after implantation. RESULTS: No adverse secondary effects were seen after the application of the fibrin glue sealant. The incidence of exit/tunnel infection and peritonitis was similar in the two groups. The incidence of leakage was significantly lower in the sealant group (p < 0.02). In the early-used catheters, leakage was detected in 9% of the catheters in the sealant group and in 57% of the control group (p < 0.05). CONCLUSIONS: The application of 1 mL of fibrin glue to the peritoneal cuff suture prevented early dialysate leakage without secondary adverse effects in children on CPD.
机译：目的：评估在腹膜袖带缝合中使用纤维蛋白胶密封剂是否可预防慢性腹膜透析（CPD）终末期肾脏疾病患儿的早期透析液渗漏。设计：单中心，开放标签，前瞻性随机研究。单位：大学儿科医院。方法：在45名儿童（平均年龄6.2 +/- 4.5岁）中植入了52条导管。将导管随机分配到对照组或密封剂组。在后一组中，将1 mL纤维蛋白胶密封剂应用于腹膜袖带缝合线。植入后5天内首次使用18个导管（早期使用的导管）。在植入后的最初60天内，评估了渗漏，出口部位或隧道感染，腹膜炎和不良继发效应。结果：应用纤维蛋白胶密封剂后未观察到不良的继发作用。两组的出口/隧道感染和腹膜炎的发生率相似。密封剂组的泄漏发生率明显较低（p <0.02）。在早期使用的导管中，密封剂组和对照组的9％的导管中均检出了渗漏（p <0.05）。结论：在腹膜袖带缝合中使用1 mL纤维蛋白胶可防止早期透析液渗漏，而对CPD儿童无继发性不良影响。

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