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首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Gender differences in normalized clearances in CAPD: role of body size and normalizing parameters.
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Gender differences in normalized clearances in CAPD: role of body size and normalizing parameters.

机译：CAPD标准化清除率的性别差异：体型和标准化参数的作用。

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OBJECTIVE: To compare raw (not normalized) and normalized urea and creatinine clearances between women and men on continuous ambulatory peritoneal dialysis (CAPD). To study whether potential gender differences are due to the normalization process. DESIGN: Retrospective analysis of clearance studies. SETTING: Dialysis units of four academic medical centers. PARTICIPANTS: The study included 302 subjects (135 women and 167 men) on CAPD with four daily exchanges and a 2-L exchange volume. INTERVENTION: Measurement of urea and creatinine clearances (261 in women, 352 in men) by standard methods. Body water (the volume of distribution, V, for both urea and creatinine) was estimated by the Watson anthropometric formulas. MAIN OUTCOME MEASURES: Comparison of raw and normalized clearances between women and men. Urea clearance was normalized by V (Kt/Vur), while creatinine clearances was normalized by both V (Kt/Vcr) and body surface area (BSA) (Ccr). RESULTS: Mean values of weekly total (peritoneal plus renal) raw clearances were higher in men (urea clearance: women 67.1 L, men 77.4 L; Ccr: women 61.7 L, men 78.3 L). Raw renal clearances were higher in men, while raw peritoneal clearances were comparable. Mean weekly total Kt/Vur was higher in women (2.19 vs 1.94 in men), mean weekly total Kt/Vcr did not differ between the genders (women 2.01, men 1.95), while mean weekly Ccr was higher in men (73.0 vs 64.7 L/1.73 m2 in women). When clearances differed, the differences were significant at p < 0.001. Men had greater height and weight, while women had greater body mass index. On the average, V in men exceeded V in women by 31%, while BSA in men exceeded BSA in women by only 12%. CONCLUSIONS: Normalization of clearances by V creates relatively higher clearance values in women, while normalization by BSA creates relatively higher clearance values in men. Thus the normalization process may create artificial differences in the normalized clearances between genders.
机译：目的：比较连续非卧床腹膜透析（CAPD）中男女的原始（未标准化）和标准化尿素和肌酐清除率。研究潜在的性别差异是否归因于正常化过程。设计：清除研究的回顾性分析。地点：四个学术医学中心的透析室。参与者：该研究包括302名CAPD受试者（135名女性和167名男性），每天进行四次交换，交换量为2-L。干预：通过标准方法测量尿素和肌酐清除率（女性为261，男性为352）。人体水分（尿素和肌酐的分布体积，V）通过沃森人体测量公式估算。主要观察指标：男女原始和正常清除率的比较。尿素清除率通过V（Kt / Vur）进行归一化，而肌酐清除率通过V（Kt / Vcr）和体表面积（BSA）（Ccr）进行归一化。结果：男性每周总（腹膜和肾脏）原始清除率的平均值较高（男性：尿素清除率：女性67.1 L，男性77.4 L; Ccr：女性61.7 L，男性78.3 L）。男性的原始肾脏清除率更高，而原始的腹膜清除率相当。女性的平均每周总Kt / Vur较高（男性为2.19比1.94），性别之间的平均每周总Kt / Vcr无差异（女性2.01，男性为1.95），而男性的平均每周Ccr较高（73.0比64.7） L / 1.73平方米（女性）。当间隙不同时，差异显着，p <0.001。男人的身高和体重更大，而女人的体重指数更大。平均而言，男性的V比女性的VSA高31％，而男性的BSA仅比女性的BSA高12％。结论：V归一化清除率在女性中产生相对较高的清除率值，而BSA归一化产生于男性中相对较高的清除率值。因此，标准化过程可能会在性别之间的标准化清除率中造成人为差异。

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